Paper Details

  1. Home
  2. Paper Details

The anticonvulsant effect of chronic treatment with topiramate after pilocarpine-induced status epilepticus is accompanied by a suppression of comorbid behavioral impairments and robust neuroprotection in limbic regions in rats.

Author: AtanasovaDimitrinka, AtanasovaMilena, IoaniduLyubka, PeychevLyudmil, Shishmanova-DosevaMichaela, TchekalarovaJana, UzunovaYordanka

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effects of topiramate (TPM) on spontaneous motor seizures, mood and cognitive impairments, neuronal loss, oxidative stress, and inflammation in a rat model of temporal lobe epilepsy (TLE). TPM treatment effectively suppressed seizures and associated behavioral impairments but did not significantly reduce oxidative stress or inflammation.
Paper Details　
Original Abstract of the Article :
Epilepsy is a widespread neurological disorder frequently associated with a lot of comorbidities. The present study aimed to evaluate the effects of the antiseizure medication topiramate (TPM) on spontaneous motor seizures, the pathogenesis of comorbid mood and cognitive impairments, hippocampal neu...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.yebeh.2022.108802

データ提供：米国国立医学図書館（NLM）

Topiramate: Combating Epilepsy and Its Comorbidities

Epilepsy, a neurological disorder characterized by recurrent seizures, often poses challenges beyond the seizures themselves. This research examines the effects of topiramate, an anticonvulsant medication, on both seizures and comorbidities in a rat model of temporal lobe epilepsy (TLE). The authors demonstrate that chronic topiramate treatment effectively reduces spontaneous motor seizures, offering significant neuroprotection in limbic regions. Moreover, they highlight the ability of topiramate to mitigate comorbid behavioral impairments, suggesting its potential as a multifaceted treatment for epilepsy.

A Multifaceted Approach: Topiramate for Epilepsy and Its Comorbidities

This research underscores the potential of topiramate to not only control seizures but also address the comorbidities associated with epilepsy. The authors' findings suggest that topiramate can offer a more comprehensive approach to managing this challenging condition, potentially improving overall patient outcomes.

A Holistic Perspective: Addressing the Whole Person

This research emphasizes the importance of a holistic approach to epilepsy management, addressing not only the seizures but also the associated comorbidities. The authors' findings highlight the potential of topiramate to provide comprehensive relief, potentially improving quality of life for individuals living with this complex condition. Open communication with healthcare professionals is essential for discussing treatment options and determining the most appropriate course of action for individual needs.

Dr. Camel's Conclusion

This research demonstrates the potential of topiramate to effectively control seizures and mitigate comorbid behavioral impairments in a rat model of temporal lobe epilepsy. The authors' findings suggest that topiramate can offer a more comprehensive approach to managing this challenging condition, potentially improving overall patient outcomes.

Date :
  1. Date Completed 2022-08-30
  2. Date Revised 2022-11-01
Further Info :

Pubmed ID

35792414

DOI: Digital Object Identifier

10.1016/j.yebeh.2022.108802

Related Literature

Article Analysis
・Side Effects of pilocarpine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.