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MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis.

Author: LanQin, LiMin, LiRongqi, WangChenxiang, XuShaolin, YeZhongjiang, YingLili, YuZheng, ZhangXiuhua, ZhouZiye

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Crizotinib (CRIZO), used to treat non-small-cell lung cancer, can cause hepatic inflammatory injury, limiting its clinical use. This study suggests that CRIZO promotes autophagy activation and pyroptosis via ROS accumulation and that magnesium isoglycyrrhizinate (MgIG) may offer therapeutic effects by reducing ROS levels and protecting against CRIZO-induced hepatotoxicity.
Paper Details　
Original Abstract of the Article :
Crizotinib (CRIZO) has been widely employed to treat non-small-cell lung cancer. However, hepatic inflammatory injury is the major toxicity of CRIZO, which limits its clinical application, and the underlying mechanism of CRIZO-induced hepatotoxicity has not been fully explored. Herein, we used cell ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357634/

データ提供：米国国立医学図書館（NLM）

Magnesium Isoglycyrrhizinate: A Potential Solution for Crizotinib-Induced Hepatotoxicity

This study investigates the mechanisms behind crizotinib (CRIZO)-induced hepatotoxicity, a serious side effect of this cancer drug. The researchers identified the role of reactive oxygen species (ROS) in triggering liver damage. The study also found that magnesium isoglycyrrhizinate (MgIG) can effectively protect the liver from CRIZO-induced injury. This research has significant implications for the safe and effective use of CRIZO in treating lung cancer.

MgIG Offers a Potential Solution for a Common Problem

The study reveals the mechanisms by which CRIZO can damage the liver and highlights the potential of MgIG as a protective agent. This is important because CRIZO-induced hepatotoxicity is a common concern, limiting its clinical application. The discovery of MgIG's protective effects could lead to new strategies for minimizing liver damage in patients receiving CRIZO treatment.

Protecting the Liver: A Vital Step in Cancer Treatment

This research emphasizes the importance of protecting the liver during cancer treatment. Liver damage can significantly affect a patient's overall health and ability to tolerate treatment. The study's findings suggest that MgIG could play a crucial role in safeguarding liver function during CRIZO therapy, potentially improving treatment outcomes and reducing the risk of complications.

Dr. Camel's Conclusion

This study is a reminder that even with advancements in cancer treatment, it's crucial to consider the potential side effects and develop strategies for mitigating these risks. The discovery of MgIG's protective effects against CRIZO-induced hepatotoxicity offers a glimmer of hope for improving the safety and efficacy of this important cancer drug.

Date :
  1. Date Completed 2022-08-09
  2. Date Revised 2022-09-06
Further Info :

Pubmed ID

35855570

DOI: Digital Object Identifier

PMC9357634

Related Literature

Article Analysis
・Effects of crizotinib
SNS
PICO Info
in preparation
Languages

English

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