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S-Adenosylmethionine Inhibits Colorectal Cancer Cell Migration through Mirna-Mediated Targeting of Notch Signaling Pathway.
Author: ArpinoRoberta, BorzacchielloLuigi, CacciapuotiGiovanna, GrilloRoberta, MoscaLaura, PorcelliMarina, Veglia TrancheseRoberta
Original Abstract of the Article :
Metastasis is a leading cause of mortality and poor prognosis in colorectal cancer (CRC). Thus, the identification of new compounds targeting cell migration represents a major clinical challenge. Recent findings evidenced a central role for dysregulated Notch in CRC and a correlation between Notch o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320859/
データ提供：米国国立医学図書館（NLM）
S-Adenosylmethionine: A Potential Weapon Against Colorectal Cancer Metastasis
Metastasis, the spread of cancer to distant sites, is a major challenge in colorectal cancer (CRC) treatment. This research delves into the potential of S-adenosyl-L-methionine (AdoMet), a crucial methyl donor in cellular processes, as a novel antimetastatic agent. The researchers investigated AdoMet's effects on CRC cell migration and its potential to regulate the Notch signaling pathway, a critical player in CRC development and metastasis. They also examined the role of microRNAs (miRNAs) in mediating AdoMet's effects on Notch signaling.
AdoMet's Potential: Regulating Notch and Inhibiting Migration
The study found that AdoMet significantly inhibited CRC cell migration and reduced the expression of proteins involved in cell migration and epithelial-mesenchymal transition (EMT), a key process in metastasis. Importantly, AdoMet was found to upregulate specific onco-suppressor miRNAs, including miR-34a, miR-34c, and miR-449a. These miRNAs directly target Notch, suggesting a potential mechanism for AdoMet's antimetastatic effects.
Unlocking the Potential of AdoMet
The study's findings highlight AdoMet's potential as a novel Notch inhibitor and suggest its antimetastatic effects involve the miRNA-mediated targeting of Notch signaling. These findings open new avenues for developing more effective treatments to combat CRC metastasis. Further research is needed to validate AdoMet's efficacy and safety in clinical settings, potentially paving the way for new therapeutic strategies in the fight against CRC.
Dr.Camel's Conclusion
Just as a camel adapts to the harsh desert environment, researchers are relentlessly searching for new strategies to combat the relentless spread of colorectal cancer. This study suggests AdoMet holds promise as a potential weapon against metastasis, highlighting the intricate interplay between miRNAs, Notch signaling, and cellular processes. Further research will help us better understand AdoMet's full potential and pave the way for more targeted and effective treatments.
Date :
- Date Completed 2022-07-28
- Date Revised 2022-07-31
Further Info :
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