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Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice.

Author: DonedaDiego Luiz, FernandesIsadora Luiza, Rios-SantosFabrício, RohdenChristopher Alecsander Herane, Vandresen-FilhoSamuel, ViolaGiordano Gubert, da SilvaRozielly Aparecida Lemes, da Silva BussZiliani, de ArrudaCristina Maria, de LimaEliângela, de MatosYohan Alves Victor, de OliveiraVinícius Vezzi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the antidepressant-like effects of vilazodone in mice. Vilazodone is an antidepressant that is used to treat major depressive disorder. The researchers found that vilazodone reduced immobility time in the tail suspension test, suggesting an antidepressant-like effect. They also found that this effect was mediated by the kynurenine pathway and N-methyl-D-aspartate receptors.
Paper Details　
Original Abstract of the Article :
The present study evaluated the antidepressant-like effects of vilazodone using the tail suspension test in mice. We also investigated the contribution of kynurenine pathway and N-methyl-d-aspartate receptors to this effect. For this purpose, we pretreated animals with sub-effective doses of L-kynur...See full text at original site
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引用元：
https://doi.org/10.1016/j.pbb.2022.173433

データ提供：米国国立医学図書館（NLM）

Exploring the Antidepressant-Like Effects of Vilazodone: Role of the Kynurenine Pathway and NMDA Receptors

In the field of [neuropharmacology], understanding the mechanisms of action of antidepressants is crucial for developing effective treatments for depression. This study investigates the antidepressant-like effects of [vilazodone] using the tail suspension test in mice. The authors explore the potential involvement of the kynurenine pathway and N-methyl-d-aspartate (NMDA) receptors in mediating the antidepressant-like effects of vilazodone. Their findings shed light on the potential mechanisms underlying vilazodone's therapeutic action.

Vilazodone Shows Antidepressant-Like Effects Linked to Kynurenine Pathway and NMDA Receptors

The study demonstrates that vilazodone exhibits antidepressant-like effects in the tail suspension test, and these effects are modulated by the kynurenine pathway and NMDA receptors. This finding suggests that vilazodone may exert its therapeutic action through interactions with these specific pathways, offering new insights into its potential mechanism of action.

Navigating the Complexities of Depression Treatment

This research highlights the complexity of depression and the need for a multifaceted approach to treatment. By understanding the intricate interactions between antidepressants, neurochemical pathways, and brain receptors, researchers can develop more targeted and effective therapies for depression.

Dr.Camel's Conclusion

Imagine a camel navigating a vast desert, seeking a source of water. This research explores the complex pathways involved in the treatment of depression, highlighting the potential of vilazodone as a therapeutic oasis. By understanding the intricacies of the kynurenine pathway and NMDA receptors, researchers are paving the way for more targeted and effective treatments for this debilitating condition.
Date :
  1. Date Completed 2022-08-09
  2. Date Revised 2022-08-23
Further Info :

Pubmed ID

35901966

DOI: Digital Object Identifier

10.1016/j.pbb.2022.173433

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Article Analysis
・Effects of vilazodone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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