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Chronic intermittent hypoxia, a hallmark of obstructive sleep apnea, promotes 4T1 breast cancer development through endothelin-1 receptors.

Author: BouyonSophie, Briançon-MarjolletAnne, Godin-RibuotDiane, GonthierBrigitte, Hazane-PuchFlorence, JosserandVéronique, KotzkiSylvain, LemariéEmeline, MinovesMélanie, PépinJean-Louis, VollaireJulien

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the impact of intermittent hypoxia (IH) on breast cancer development in vitro and in vivo. IH is a hallmark of obstructive sleep apnea (OSA), a common sleep disorder. The researchers found that IH promoted breast cancer growth and malignancy in vitro and in vivo and that this effect was reversed by a dual endothelin receptor antagonist.
Paper Details　
Original Abstract of the Article :
The association between obstructive sleep apnea (OSA) and cancer is still debated and data are scarce regarding the link between OSA and breast cancer progression. Since conclusive epidemiological studies require large sample sizes and sufficient duration of exposure before incident cancer occurrenc...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334573/

データ提供：米国国立医学図書館（NLM）

Chronic Intermittent Hypoxia Promotes Breast Cancer Development

In the vast desert of cancer research, scientists are always seeking to unravel the complex mechanisms that drive disease progression. This study investigates the effects of chronic intermittent hypoxia (IH) on breast cancer development. IH is a hallmark of obstructive sleep apnea (OSA), a condition characterized by repeated pauses in breathing during sleep. This research explores the link between IH and breast cancer, which is like uncovering a hidden path in a desert that leads to a dangerous oasis.

Intermittent Hypoxia and Breast Cancer

The researchers discovered that chronic IH exposure promotes breast cancer growth and malignancy. This is like a sandstorm that creates a fertile ground for harmful organisms to thrive. They also found that this effect was mediated by the endothelin signaling pathway. The researchers used a combination of in vitro and in vivo models to study the effects of IH on breast cancer cells, which is like testing different strategies for navigating a treacherous desert.

Health Benefits and Lifestyle Implications

This research provides evidence for the potential link between OSA and breast cancer, highlighting the importance of addressing sleep disorders. It's like finding a hidden wellspring of health in a desert, where addressing a seemingly unrelated issue can have a positive impact on overall well-being. This study emphasizes the need to be mindful of sleep quality and to seek treatment for OSA, especially for individuals with a history of breast cancer or a high risk of developing the disease.

Dr. Camel's Conclusion

This research sheds light on the potential role of sleep disorders in cancer development. It's like uncovering a hidden connection between the sandstorms of sleep apnea and the growth of harmful organisms in a desert. This study provides a valuable reminder that addressing sleep disorders is essential for overall health and may play a role in preventing and managing cancer.

Date :
  1. Date Completed 2022-08-01
  2. Date Revised 2022-11-17
Further Info :

Pubmed ID

35902610

DOI: Digital Object Identifier

PMC9334573

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Languages

English

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