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Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats.
Author: BroeckxBart J G, DevreeseMathias, HellemansArnaut, PaepeDominique, Roche-CatholyMarine, SchneiderMarc, SmetsPascale, WoehrléFrederique, de Salazar AlcalaAndrea Garcia
Original Abstract of the Article :
BACKGROUND: In people and dogs, torasemide has higher bioavailability, longer half-life, and longer duration of action than equivalent doses of furosemide but data regarding pharmacological properties of torasemide in cats are limited. OBJECTIVE: To assess pharmacokinetic and pharmacodynamic parame...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9511087/
データ提供:米国国立医学図書館(NLM)
Torasemide: A Novel Approach to Diuresis in Cats
Feline medicine is constantly evolving, seeking to address the unique needs of our feline companions. This study delves into the pharmacokinetic and pharmacodynamic properties of torasemide, a loop diuretic, in healthy cats. The researchers sought to understand the effects of torasemide on diuresis, electrolyte balance, and the renin-angiotensin-aldosterone system (RAAS) in cats.
The researchers conducted a study involving six healthy cats, administering a single dose of torasemide and monitoring various physiological parameters. They discovered that torasemide had a high bioavailability, a long half-life, and a significant diuretic effect. The study also revealed that torasemide activated the RAAS, leading to a transient decrease in plasma potassium concentration. However, the authors found no significant effects on blood pressure or plasma creatinine concentration.
Optimizing Diuretic Therapy for Cats
This study provides valuable insights into the effects of torasemide in cats, offering guidance for its clinical use. The authors' findings suggest that torasemide may be a useful diuretic for cats, providing a longer duration of action and a higher bioavailability than furosemide. The study also highlights the importance of monitoring electrolyte balance and considering potential activation of the RAAS when using torasemide in cats.
Dr. Camel's Conclusion
This study reminds us that the desert of veterinary medicine is constantly evolving, with new discoveries and innovations emerging to improve the health and well-being of our animal companions. The researchers' findings offer a promising new approach to diuretic therapy for cats, potentially leading to more effective and convenient treatment options for a variety of feline conditions.
Date :
- Date Completed 2022-09-28
- Date Revised 2022-10-01
Further Info :
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