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A dual-responsive "Yin-Yang" photothermal delivery system to accelerate Parthenolide anti-tumor efficacy.

Author: DengYuwei, GaoWenbin, GuHao, JiangXinquan, LiAnshuo, WenJin, ZhangXuwu, ZhuYuhui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes the development of a dual-responsive delivery system for parthenolide (PTL), a natural compound with anticancer properties. The system uses liposomes, chitosan, and gold nanoshells to deliver PTL to tumor cells and release it upon exposure to light or acidic environments.
Paper Details　
Original Abstract of the Article :
Parthenolide (PTL), a germacrane sesquiterpene lactone extracted from the "Yin" Chinese traditional herb feverfew, has gained interest due to its lethal effects on tumor cells and its pharmacological effects within traditional Chinese medicine theory. To overcome low, non-targeted accumulation and u...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/j.bioadv.2022.212935

データ提供：米国国立医学図書館（NLM）

A Dual-Responsive Delivery System for Enhanced Parthenolide Anti-Tumor Efficacy

This study explores the development of a novel dual-responsive delivery system for Parthenolide (PTL), a potent anti-cancer agent derived from the feverfew plant. The researchers engineered a system that combines liposomes, chitosan, and gold nanoshells to achieve both light- and pH-responsive release of PTL. The system utilizes the heat generated by gold nanoshells under near-infrared light irradiation to trigger PTL release and enhance its anti-tumor efficacy. The study suggests that this dual-responsive system may offer a promising strategy for improving the effectiveness of PTL treatment for cancer.

Dual-Responsive Delivery System: A New Frontier in Cancer Therapy

The study's development of a dual-responsive delivery system for PTL opens new possibilities for targeted and effective cancer therapy. The ability to control PTL release in a highly targeted manner may lead to improved treatment outcomes and reduced side effects.

Precision Medicine for Cancer Treatment

This study highlights the growing trend of precision medicine in cancer treatment. By developing targeted delivery systems, researchers are aiming to improve the effectiveness of cancer therapies and minimize adverse effects.

Dr.Camel's Conclusion

Imagine a camel caravan traveling through the desert, each camel carrying a precious cargo. This study introduces a new caravan, a dual-responsive delivery system, carrying the powerful anti-cancer agent PTL. By using this innovative system, we can potentially deliver PTL more effectively and with greater precision, aiming for a more successful journey in the fight against cancer.

Date :
  1. Date Completed 2022-08-03
  2. Date Revised 2022-08-03
Further Info :

Pubmed ID

35913256

DOI: Digital Object Identifier

10.1016/j.bioadv.2022.212935

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Article Analysis
・Effective treatment of feverfew
SNS
PICO Info
in preparation
Languages

English

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