An Open-Label Study to Evaluate the Effect of Eluxadoline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Participants.

Author: BoinpallyRamesh, KaczynskiEdward, McGeeneyDanielle, WeissmanDarren

Paper Details 
Original Abstract of the Article :
Eluxadoline is a mixed μ-opioid, κ-opioid receptor agonist, and δ-opioid receptor antagonist, approved in the United States for adults with diarrhea-predominant irritable bowel syndrome. This phase 1, single-center, open-label, single-sequence study was conducted on 30 healthy participants to establ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805131/

データ提供:米国国立医学図書館(NLM)

Eluxadoline: No Clinically Significant Effect on Midazolam Pharmacokinetics

Medications, like desert plants, can interact in unexpected ways. This study investigated the potential interaction between eluxadoline, a drug used to treat diarrhea-predominant irritable bowel syndrome, and midazolam, a commonly used sedative. The researchers wanted to determine if eluxadoline could affect the body's processing of midazolam.

Eluxadoline Does Not Significantly Affect Midazolam Metabolism

The study found that eluxadoline did not have a clinically significant effect on the pharmacokinetics of midazolam, suggesting that it is unlikely to affect the effectiveness of other medications metabolized by the same enzyme.

Navigating the Desert of Drug Interactions

This research provides reassurance about the safety of eluxadoline in combination with other medications. However, it is always important to consult with a healthcare professional to discuss potential drug interactions and ensure safe and effective treatment outcomes.

Dr. Camel's Conclusion

This study provides valuable information about the drug interaction profile of eluxadoline. It highlights the importance of understanding potential drug interactions, just as a camel needs to be aware of the hidden dangers of the desert. This research reinforces the need for ongoing vigilance and careful consideration of medication combinations to ensure patient safety.

Date :
  1. Date Completed 2022-11-02
  2. Date Revised 2023-01-25
Further Info :

Pubmed ID

35938453

DOI: Digital Object Identifier

PMC9805131

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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