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Screening immune adjuvants for an inactivated vaccine against <i>Erysipelothrix rhusiopathiae</i>.

Author: DingKe, GuanLi-Jun, HanYi-Nong, PeiShi-Xuan, SongJi-Jian, XueYun, ZhanPeng-Fei, ZhaoZhan-Qin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study looked at different adjuvants, or substances that help vaccines work better, for a vaccine against _Erysipelothrix rhusiopathiae_, a bacteria that can cause disease in pigs. The study found that a water-soluble polymer called GEL02 was the best adjuvant for this vaccine.
Paper Details　
Original Abstract of the Article :
In this study, we screened adjuvants for an inactivated vaccine against <i>Erysipelothrix rhusiopathiae</i> (<i>E. rhusiopathiae</i>). Inactivated cells of <i>E. rhusiopathiae</i> strain HG-1 were prepared as the antigen in five adjuvanted inactivated vaccines, including a mineral-oil-adjuvanted vac...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360596/

データ提供：米国国立医学図書館（NLM）

Searching for the Perfect Adjuvant for an Erysipelothrix rhusiopathiae Vaccine

Protecting against bacterial infections is a constant challenge in the world of veterinary medicine. This study focused on finding the optimal adjuvant for an inactivated vaccine against Erysipelothrix rhusiopathiae, a bacterium that can cause serious infections in pigs and other animals. The researchers evaluated the effectiveness of various adjuvants, including mineral oil, aluminum hydroxide gel, and water-soluble polymers, in boosting the immune response to the inactivated E. rhusiopathiae antigen.

GEL: A Promising Adjuvant for E. rhusiopathiae Vaccine

Through a series of experiments in mice and piglets, the study identified GEL02, a water-soluble polymer, as the most effective adjuvant for the inactivated vaccine against E. rhusiopathiae. The GEL-adjuvanted vaccine demonstrated superior protection against challenge with the bacterium compared to other adjuvants, suggesting its potential as a valuable tool in preventing E. rhusiopathiae infections in livestock.

A Step Towards Safer and More Effective Vaccine Protection

This study highlights the importance of choosing the right adjuvant for developing effective vaccines. The identification of GEL as a promising adjuvant for an E. rhusiopathiae vaccine opens new avenues for developing safer and more effective vaccines to protect livestock and potentially humans from this bacterium. Further research is needed to refine the use of GEL and explore its application in other vaccine formulations.

Dr.Camel's Conclusion

Just as the desert sands shift and change, so too do the challenges we face in protecting against infectious diseases. This study reveals the potential of a water-soluble polymer adjuvant, GEL, in boosting the effectiveness of a vaccine against Erysipelothrix rhusiopathiae. This finding could help us develop safer and more effective vaccines for livestock, ensuring their health and well-being.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-08-13
Further Info :

Pubmed ID

35958306

DOI: Digital Object Identifier

PMC9360596

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Languages

English

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