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Selenium substituted axitinib reduces axitinib side effects and maintains its anti-renal tumor activity.
Author: Ahmad RidwanKadir, FuYing, KongXiangshun, RongYao, SaxuRengui, TengYuou, YuPeng, ZhaoCai, ZhengWeida
Original Abstract of the Article :
Axitinib is a potent vascular endothelial growth factor receptor (VEGFR) inhibitor, which has a strong inhibitory effect on the three isoforms of VEGFR 1-3. Having strong therapeutic efficacy, its broad use is limited by its side effects such as hypertension, proteinuria, cardiovascular damage, and ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358677/
データ提供:米国国立医学図書館(NLM)
A New Hope for Renal Cell Carcinoma Treatment
This study delves into the realm of [oncology] and seeks to address the challenges of treating [renal cell carcinoma (RCC)]. Axitinib, a powerful [vascular endothelial growth factor receptor (VEGFR) inhibitor], has demonstrated significant effectiveness against RCC. However, its use is often limited by [severe side effects, including hypertension, proteinuria, cardiovascular damage, and liver and kidney dysfunction]. This study explores the potential of [selenium-substituted axitinib (Se-axitinib)] as a safer alternative to standard axitinib. The researchers found that [Se-axitinib retained potent antitumor activity against RCC] while [significantly reducing axitinib-related side effects].Selenium to the Rescue: A Safer Path to Cancer Treatment
This research provides a glimmer of hope for patients with [RCC] who are seeking safer treatment options. It's like finding a hidden oasis in the vast desert – a place of respite and relief from the harsh conditions. The study suggests that [Se-axitinib] could offer a more tolerable treatment approach for patients with [RCC], allowing them to experience the benefits of targeted therapy with fewer side effects.Improving Patient Outcomes: The Promise of Safer Therapies
The development of [Se-axitinib] could have a significant impact on the treatment of [RCC]. By minimizing the debilitating side effects of axitinib, this new compound could [improve patient quality of life] and potentially [extend survival]. It's a testament to the ingenuity of researchers who are continually striving to [develop safer and more effective therapies] for those battling cancer.Dr.Camel's Conclusion
This study is a beacon of hope in the fight against [RCC], offering a potential solution to the [side effect] burden associated with standard therapy. It's a reminder that innovation and collaboration are essential for finding new ways to combat this deadly disease. As researchers continue to push the boundaries of [oncology], we can expect more groundbreaking discoveries that improve the lives of those affected by cancer.Date :
- Date Completed n.d.
- Date Revised 2022-09-06
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