IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity.

Author: Bloms-FunkePetra, BoeslIrmgard, CaspaniOmbretta, ChapmanSonya C, Di PietroGiuseppe, Di StefanoGiulia, FinnerupNanna Brix, Garcia-LarreaLuis, GoetzMarcus, HernandezJose Miguel Vela, LeoneCaterina, LiTom, MourauxAndré, PelzBernhard, PhillipsKeith G, Pogatzki-ZahnEsther, SchilderAndreas, SchnetterErik, SchubartKarin, TraceyIrene, TreedeRolf-Detlef, TroconizInaki F, TruiniAndrea, Van NielHans, VincentKaty, VollertJan, WanigasekeraVishvarani, WittayerMatthias

Overview

IMI2-PainCare-BioPain-RCT2 is a clinical study aiming to profile a set of functional biomarkers of drug effects on the nociceptive system to accelerate the development of analgesics.

Paper Details　

Original Abstract of the Article :

IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-BioPain-RCT2 will foc...See full text at original site

Dr.Camel's Paper Summary Blog

IMI2-PainCare-BioPain-RCT2 Protocol: A Randomized, Double-Blind, Placebo-Controlled, Crossover, Multicenter Trial

The study of pain is a complex and often treacherous desert, filled with mysteries that researchers strive to unravel. This research delves into the effects of lacosamide, pregabalin, and tapentadol on pain processing, focusing on human spinal cord and brainstem activity. Through a meticulously designed multicenter trial, the authors aim to identify functional biomarkers of drug effects on specific compartments of the nociceptive system. This research contributes to a deeper understanding of pain pathways and the potential for developing new and more effective analgesics. A key aspect of this study is its focus on non-invasive neurophysiological measurements, offering a promising avenue for future research and development of pain treatments.

Unveiling the Mysteries of Pain

This research, like a seasoned explorer venturing into a new desert, seeks to unravel the complexities of pain processing. The study's focus on identifying biomarkers of drug effects on the nociceptive system holds great promise for advancing our understanding of pain and developing more effective pain management strategies. The meticulous design of this multicenter trial provides a robust framework for generating reliable and generalizable findings.

A Path to Better Pain Management

This research offers a beacon of hope in the desert of pain, promising to pave the way for more effective pain management strategies. The study's focus on non-invasive neurophysiological measurements and the identification of biomarkers for drug effects holds great promise for future research and development of new analgesics. By understanding the nuances of pain processing and the mechanisms by which drugs influence this process, we can work towards a brighter future for those suffering from pain.

Dr.Camel's Conclusion

This research, like a caravan traversing a vast desert, seeks to understand the complexities of pain and develop more effective treatments. The study's meticulous design and focus on non-invasive neurophysiological measurements provide a promising path for future research and development. As researchers continue to explore the desert of pain, this study serves as a valuable guidepost, guiding us towards a brighter future for those seeking relief.