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Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones.

Author: AlquicerGlenda, BalcaenTim, BardovaKristina, BenovaAndrea, CajkaTomas, DzubanovaMartina, FerencakovaMichaela, FundaJiri, HorakovaOlga, KerckhofsGreet, KopeckyJan, MracekTomas, PecinovaAlena, ProchazkaJan, RossmeislMartin, SpoutilFrantisek, TencerovaMichaela, WillekensWouter, van LentheG Harry

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This abstract discusses the potential side effects of thiazolidinediones (TZDs), a class of drugs used to treat diabetes. TZDs can increase the accumulation of bone marrow adipocytes, leading to a higher fracture risk and bone loss. The abstract explores the effect of a novel TZD analog, MSDC-0602K, on bone phenotype and bone marrow mesenchymal stem cells in relation to obesity.
Paper Details　
Original Abstract of the Article :
The use of thiazolidinediones (TZDs) as insulin sensitizers has been shown to have side effects including increased accumulation of bone marrow adipocytes (BMAds) associated with a higher fracture risk and bone loss. A novel TZD analog MSDC-0602K with low affinity to PPARγ has been developed to redu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508355/

データ提供：米国国立医学図書館（NLM）

A New Thiazolidinedione Analog for Bone Health: Hope for the Obese

Obesity is a growing global health concern, often leading to metabolic complications like diabetes and bone loss. This research focuses on the impact of thiazolidinediones (TZDs), commonly used to treat diabetes, on bone health. The authors investigated the effects of a novel TZD analog, MSDC-0602K, on bone phenotype and bone marrow mesenchymal stem cells (BM-MSCs) in obese mice.

Potential for Reducing Bone Loss in Obese Individuals

The study revealed that MSDC-0602K, with its lower affinity for PPARγ, demonstrated a positive impact on bone health, potentially reducing the negative effects associated with classical TZDs. This finding suggests that MSDC-0602K could be a promising therapeutic agent for managing bone loss in obese individuals.

Navigating the Desert of Bone Health

The researchers compared the effects of MSDC-0602K to a classic TZD, like comparing a resilient camel traversing a harsh desert landscape to a less adaptable creature. The results suggest that MSDC-0602K could pave a path towards better bone health in obese individuals, offering a glimmer of hope for maintaining strong bones despite the challenges of obesity.

Dr. Camel's Conclusion

The desert of obesity often presents challenges for bone health. This research, like a beacon guiding a weary traveler, offers a promising new therapeutic avenue for maintaining bone strength in obese individuals. MSDC-0602K, with its reduced side effects, may be a key to healthier bones and a more robust journey through the desert of obesity.

Date :
  1. Date Completed 2022-10-11
  2. Date Revised 2022-11-01
Further Info :

Pubmed ID

36103974

DOI: Digital Object Identifier

PMC9508355

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