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Teratogenicity and Fetal-Transfer Assessment of the Retinoid X Receptor Agonist Bexarotene.
Author: AkehiMasaru, Azuma-NishiiMidori, Fujita-TakahashiManami, HiranoHiroyuki, KakutaHiroki, KatoIzumi, NozakiRui, SasakiTakanori, TakamuraYuta, WatanabeMasaki
Original Abstract of the Article :
Bexarotene, a retinoid X receptor (RXR) agonist, is used to treat cutaneous T-cell lymphoma, and drug repositioning research has also been reported, despite warnings of teratogenicity. However, fetal transfer of bexarotene and its effect on rat fetal bone formation have not been examined. In this st...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469495/
データ提供:米国国立医学図書館(NLM)
Bexarotene: A Desert Oasis in Cancer Treatment?
Bexarotene, a retinoid X receptor agonist, shows promise in treating cutaneous T-cell lymphoma, like a beacon of hope in a desert landscape. This study delves into the teratogenicity and fetal transfer of bexarotene, investigating its potential impact on fetal development in rats. Researchers aimed to assess the safety of this drug during pregnancy, unraveling its effects on fetal bone formation and overall development.
Navigating the Terrain: Bexarotene and Fetal Development
Imagine a desert traveler, cautiously navigating a potentially hazardous path. This study explores the effects of bexarotene on fetal development, providing valuable insights for pregnant women and their healthcare providers. The researchers discovered that bexarotene caused fetal abnormalities in rats, highlighting the importance of careful consideration and monitoring during pregnancy.
Weighing the Risks: Bexarotene and Pregnancy
The study's findings underscore the importance of weighing the potential benefits of bexarotene against the potential risks to fetal development. This research provides crucial information for healthcare professionals and pregnant women seeking treatment for cutaneous T-cell lymphoma. Understanding the potential implications of bexarotene during pregnancy is paramount in ensuring the well-being of both mother and child.
Dr.Camel's Conclusion
While bexarotene offers hope in the treatment of cutaneous T-cell lymphoma, this study highlights the need for caution during pregnancy. Just as a desert traveler meticulously plans a safe route, healthcare providers and pregnant women must carefully consider the potential risks and benefits of this medication. The research emphasizes the importance of ongoing research to further understand the impact of bexarotene on fetal development.
Date :
- Date Completed n.d.
- Date Revised 2023-08-11
Further Info :
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