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Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice.

Author: AllenLuke B, MirnicsKároly

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the effects of beta-blockers on brain sterol biosynthesis in vitro. The findings suggest that metoprolol (MTP) may elevate levels of 7-dehydrocholesterol (7-DHC), a potentially teratogenic compound, and may be detrimental for offspring development.
Paper Details　
Original Abstract of the Article :
De novo sterol synthesis is a critical homeostatic mechanism in the brain that begins during early embryonic development and continues throughout life. Multiple medications have sterol-biosynthesis-inhibiting side effects, with potentially detrimental effects on brain health. Using LC-MS/MS, we inve...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496459/

データ提供：米国国立医学図書館（NLM）

Metoprolol: A Hidden Oasis in the Desert of Brain Development

This research delves into the complex world of brain development, specifically focusing on the effects of metoprolol, a commonly used beta-blocker medication, on sterol biosynthesis in the brain. Imagine a desert landscape where the delicate process of brain development is influenced by various factors, including medications. The study investigated the effects of metoprolol and other beta-blockers on sterol biosynthesis in vitro, using cell lines, and in vivo, using a maternal exposure model in mice.

Metoprolol's Impact on Brain Development: A Cautionary Note

The study found that metoprolol significantly elevated 7-dehydrocholesterol (7-DHC) levels in both the brains of pregnant mice and the brains, hearts, and livers of their offspring. 7-DHC is a cholesterol precursor that can be harmful in high concentrations, potentially impacting brain development.

Navigating the Desert of Pregnancy: A Prudent Approach

This research underscores the importance of carefully considering the potential effects of medications, like metoprolol, during pregnancy. The findings suggest that alternative beta-blockers might be preferable during pregnancy to minimize the potential risks to the developing brain.

Dr.Camel's Conclusion

This research is like a warning sign in the desert of pregnancy, highlighting the potential impact of metoprolol on brain development. The findings emphasize the importance of careful medication choices during pregnancy, particularly those that may affect the developing brain.

Date :
  1. Date Completed 2022-09-26
  2. Date Revised 2022-10-18
Further Info :

Pubmed ID

36139049

DOI: Digital Object Identifier

PMC9496459

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