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A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia.

Author: BiałaGrażyna, GrabowskaKarolina, KurowskaAntonina, ZiemichódWojciech

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This manuscript provides a comprehensive review of daridorexant, a selective dual-orexin receptor antagonist (DORA), for the treatment of insomnia. The review covers pharmacodynamics, animal and human research, pharmacokinetics, and safety, highlighting the drug's promising results and safety profile.
Paper Details　
Original Abstract of the Article :
Insomnia affects 4.4-4.8% of the world's population, but because the effect of hypnotic drugs is limited and may cause harmful side-effects, scientists are turning their attention to developing drugs that act on the orexin system. Daridorexant, a selective dual-orexin receptor antagonist (DORA), has...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502995/

データ提供：米国国立医学図書館（NLM）

Daridorexant: A New Hope for Insomnia

Insomnia, the inability to sleep, can significantly impact our quality of life. This research explores the potential of daridorexant, a new drug that targets the orexin system, a brain region involved in regulating sleep and wakefulness, as a treatment for insomnia. The study reviews the pharmacodynamics, preclinical and clinical data, pharmacokinetics, and safety profile of daridorexant, highlighting its potential as a novel therapeutic agent for insomnia.

Daridorexant: A New Dawn for Sleep

This research, like a camel finding a cool oasis after a long, arduous journey, offers hope for individuals struggling with insomnia. The study highlights the promising potential of daridorexant, a new medication that targets the orexin system, to effectively treat insomnia without causing significant side effects.

Getting a Good Night's Sleep: A Guide to Restful Nights

If you're struggling with insomnia, it's important to talk to your doctor. They can help you identify the underlying cause of your sleep problems and develop a personalized treatment plan. In addition to medication, there are many lifestyle strategies that can help improve sleep, such as maintaining a regular sleep schedule, creating a relaxing bedtime routine, and avoiding caffeine and alcohol before bed.

Dr. Camel's Conclusion

This research, like a camel navigating a vast and sometimes treacherous desert, sheds light on a new potential treatment for insomnia. The study highlights the promising therapeutic potential of daridorexant, offering a glimmer of hope for individuals struggling with this common sleep disorder.
Date :
  1. Date Completed 2022-09-26
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

36144776

DOI: Digital Object Identifier

PMC9502995

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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