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Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice.

Author: BenkovicsGábor, CsepregiRita, Fliszár-NyúlEszter, PoórMiklós, SzenteLajos

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the protective effects of sulfobutylether-β-CD (SBECD) and sugammadex (SGD) against chlorpromazine (CPZ)-induced acute toxicity using in vitro and in vivo models. The results suggest that SBECD may have potential as an antidote for CPZ intoxication.
Paper Details　
Original Abstract of the Article :
Chlorpromazine (CPZ) is an antipsychotic drug which can cause several adverse effects and drug poisoning. Recent studies demonstrated that CPZ forms highly stable complexes with certain cyclodextrins (CDs) such as sulfobutylether-β-CD (SBECD) and sugammadex (SGD). Since there is no available antidot...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504268/

データ提供：米国国立医学図書館（NLM）

Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice

This study delves into the fascinating world of [クロルプロマジン] toxicity and potential antidotes. The authors investigated the protective effects of sulfobutylether-β-cyclodextrin (SBECD) and sugammadex against chlorpromazine-induced acute toxicity in [細胞株] and [マウス] models. They found that SBECD demonstrated a protective effect in a dose-dependent manner, while sugammadex did not significantly affect CPZ-induced mortality. These findings highlight the potential of SBECD as a potential antidote for CPZ intoxication.

A Beacon of Hope in the Desert of Toxicity

The study found that SBECD showed promise as a potential antidote for chlorpromazine (CPZ) intoxication. The researchers observed a dose-dependent protective effect of SBECD, indicating that higher doses of SBECD were associated with greater protection against CPZ-induced toxicity. This finding offers a beacon of hope in the desert of CPZ toxicity, suggesting that SBECD could be a valuable therapeutic tool in managing CPZ poisoning.

Navigating the Hazards of Chlorpromazine

Chlorpromazine (CPZ) is a medication that can be like a desert mirage – it may offer relief but can also pose significant risks. This study provides valuable insights into the potential protective effects of sulfobutylether-β-cyclodextrin (SBECD) against CPZ-induced toxicity. Understanding these risks and potential antidotes is crucial for navigating the hazards of CPZ treatment.

Dr.Camel's Conclusion

This study investigates the potential of SBECD and sugammadex as antidotes for chlorpromazine (CPZ) intoxication. The promising results of SBECD in reducing CPZ-induced toxicity open doors for further investigation and potential clinical applications. This study serves as a reminder that continued research is essential to combat the dangers of toxic substances and improve patient safety.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

36145637

DOI: Digital Object Identifier

PMC9504268

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・Effects of chlorpromazine
SNS
PICO Info
in preparation
Languages

English

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