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Suppression of vacuolar-type ATPase and induction of endoplasmic reticulum stress by proton pump inhibitors.

Author: LeeWei-Ping

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Proton pump inhibitors (PPIs) are commonly used medications, but long-term use has been linked to an increased risk of gastric cancer. This study aims to investigate the underlying mechanism of PPI-mediated gastric cancer.
Paper Details　
Original Abstract of the Article :
Proton pump inhibitors (PPIs), such as esomeprazole, pantoprazole, dexlansoprazole, and rabeprazole, are one of the most commonly prescribed medications. Several studies have linked the long-term use of PPIs to a potentially increased risk of gastric cancer. Therefore, this study aimed to determine ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36150104

データ提供：米国国立医学図書館（NLM）

Proton Pump Inhibitors and Gastric Cancer: Exploring the Link

Proton pump inhibitors (PPIs) are widely used medications for treating acid reflux and other gastrointestinal disorders. This research article, published in the Journal of Gastroenterology, investigates the potential link between long-term PPI use and an increased risk of gastric cancer. The researchers explore the mechanisms by which PPIs may contribute to gastric cancer development, focusing on their effects on cellular processes like vacuolar-type ATPase suppression and endoplasmic reticulum stress. This is like examining the impact of a prolonged drought on a delicate desert ecosystem – understanding the subtle changes and long-term consequences is crucial for comprehending the relationship.

PPIs and Gastric Cancer: A Complex Relationship

The study suggests that PPIs may have a role in the development of gastric cancer. The researchers found that PPIs can suppress vacuolar-type ATPase and induce endoplasmic reticulum stress, potentially contributing to cellular damage and tumorigenesis.

Responsible Use of PPIs: A Call for Caution

The study highlights the importance of responsible PPI use. Healthcare professionals are encouraged to carefully consider the potential risks and benefits of PPIs, particularly for long-term use.

Dr. Camel's Conclusion

This research provides valuable insights into the potential link between PPI use and gastric cancer. While further research is needed to fully understand this complex relationship, the findings underscore the importance of responsible medication use and careful monitoring for potential side effects.

Date :
  1. Date Completed 2022-09-28
  2. Date Revised 2023-07-27
Further Info :

Pubmed ID

36150104

DOI: Digital Object Identifier

02118582-202209000-00007

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・Effects of dexlansoprazole
SNS
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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