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Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive procedures.

Author: Di PasqualeGiulia, EspositoMatteo, GalloPaolo, PicardiAntonio, TerraccianiFrancesca, Vespasiani-GentilucciUmberto

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

TPO-receptor agonists, such as avatrombopag and lusutrombopag, are promising new drugs for treating thrombocytopenia in patients with chronic liver disease. They can increase platelet production, potentially reducing the need for platelet transfusions.
Paper Details　
Original Abstract of the Article :
Chronic liver disease is characterized by several hematological derangements resulting in a complex and barely rebalanced haemostatic environment. Thrombocytopenia is the most common abnormality observed in these patients and recent advances have led to researchers focus the attention on the multifa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403422/

データ提供：米国国立医学図書館（NLM）

Thrombocytopenia in Chronic Liver Disease: New Therapeutic Strategies

Chronic liver disease is a complex condition, and patients often face a variety of challenges, including thrombocytopenia, a low platelet count. This study delves into the physiopathology of thrombocytopenia in chronic liver disease and explores new therapeutic strategies for managing this condition. It's like navigating a challenging terrain in the desert of liver disease, seeking solutions to improve the lives of patients.

The Challenges of Thrombocytopenia in Liver Disease

This study highlights the challenges of thrombocytopenia in chronic liver disease, particularly for patients requiring invasive procedures. Severe thrombocytopenia can increase the risk of bleeding, potentially delaying or even canceling life-saving interventions. It's like encountering a treacherous sandstorm in the desert, making it difficult to proceed safely.

New Hope for Thrombocytopenia Management

This study offers hope for managing thrombocytopenia in chronic liver disease. The development of new drugs, such as TPO-receptor agonists like avatrombopag and lusutrombopag, provides alternative strategies to platelet transfusions. These agents can increase platelet production, potentially reducing the need for transfusions and improving outcomes for patients. It's like discovering a new and reliable source of water in the desert, offering a more sustainable and less risky approach to managing thrombocytopenia.

Dr. Camel's Conclusion

This study, like a camel caravan bringing fresh water to a parched desert, offers hope for patients with chronic liver disease and thrombocytopenia. The development of new therapeutic strategies, such as TPO-receptor agonists, provides a potential path to safer and more effective management of this condition. It's a reminder that even in the face of seemingly insurmountable challenges, there is always the possibility of finding new and innovative solutions.

Date :
  1. Date Completed 2022-09-28
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

36157107

DOI: Digital Object Identifier

PMC9403422

SNS
PICO Info
in preparation
Languages

English

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