Paper Details 
Original Abstract of the Article :
5-fluorouracil (5FU) and capecitabine are fluoropyrimidine anti-neoplastic drugs commonly used in the treatment of different types of cancer. Hereditary dihydropyrimdine deaminase (DPD), thymidylate synthase mutations and drug overdose may lead to life-threatening toxicities. Uridine triacetate (UTA...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490183/

データ提供:米国国立医学図書館(NLM)

Uridine Triacetate: A Lifeline in the Desert of 5-Fluorouracil Toxicity

The world of cancer treatment is often a treacherous desert, with unexpected storms of side effects. This case report delves into the use of uridine triacetate (UTA) to manage delayed onset toxicity from 5-fluorouracil (5FU), a common chemotherapy drug. The researchers explore the potential benefits of UTA in a case of severe and delayed toxicity, and they review existing literature to provide a broader perspective on this critical intervention.

The researchers present a case of a patient who developed delayed neurological toxicity following 5FU treatment. This delayed response, like a hidden oasis in the desert, presented a significant challenge. However, the administration of UTA led to a remarkable improvement in the patient's condition. The case report highlights the potential of UTA as a life-saving treatment for delayed 5FU toxicity, even beyond the recommended 96-hour time window. This discovery, like a beacon in the desert, offers hope for patients facing the unpredictable challenges of chemotherapy side effects.

UTA: A Beacon in the Storm of 5-Fluorouracil Toxicity

The successful treatment of the patient with delayed 5FU toxicity using UTA demonstrates the potential of this drug to alleviate severe and life-threatening side effects. The report suggests that UTA could be considered for delayed 5FU toxicity on a case-by-case basis, even outside the standard 96-hour window.

The Camel's Compass: Navigating the Sands of Chemotherapy

This case report underscores the importance of vigilance in monitoring for delayed side effects of chemotherapy, even after the initial treatment period. It emphasizes the need for individualized patient care and proactive approaches to managing potential complications, ensuring that the treatment journey remains safe and effective. The use of UTA in this case provides a valuable tool for navigating the complex landscape of chemotherapy side effects, offering hope for patients and their families.

Dr. Camel's Conclusion

This case report highlights the potential benefits of uridine triacetate (UTA) in managing delayed onset 5-fluorouracil (5FU) toxicity. The successful treatment of a patient with delayed toxicity beyond the recommended 96-hour time window suggests that UTA could be considered for delayed 5FU toxicity on a case-by-case basis. This research underscores the importance of vigilance in monitoring for delayed side effects of chemotherapy and emphasizes the need for individualized patient care.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

36160401

DOI: Digital Object Identifier

PMC9490183

SNS
PICO Info
in preparation
Languages

English

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