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The Potential In Vitro Inhibitory Effects of Neurokinin-1 Receptor (NK-1R) Antagonist, Aprepitant, in Osteosarcoma Cell Migration and Metastasis.

Author: AlalikhanAbbas, AlsaeedMohammed Ali, EbrahimiSafieh, HashemiSeyedeh Fatemeh, HashemySeyed Isaac

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of aprepitant, a neurokinin-1 receptor (NK-1R) antagonist, on osteosarcoma cell migration and metastasis. It aimed to determine the potential of aprepitant as a therapeutic agent for osteosarcoma, a type of bone cancer.
Paper Details　
Original Abstract of the Article :
Osteosarcoma, the most frequent osteogenic malignancy, has become a serious public health challenge due to its high morbidity rates and metastatic potential. Recently, the neurokinin-1 receptor (NK-1R) is proved to be a promising target in cancer therapy. This study is aimed at determining the effec...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514929/

データ提供：米国国立医学図書館（NLM）

Exploring the Potential of Aprepitant in Combating Osteosarcoma

Osteosarcoma, a bone cancer that often metastasizes, poses a significant health threat. This study focuses on the potential of aprepitant, an NK-1R antagonist already approved by the FDA, to inhibit the migration and metastasis of osteosarcoma cells. The researchers employed a scientific approach to investigate aprepitant's effect on osteosarcoma cell movement and spread. Their findings shed light on aprepitant's potential as a therapeutic agent for osteosarcoma.

Aprepitant: A Promising Avenue for Osteosarcoma Treatment

This research provides compelling evidence that aprepitant may effectively target the NK-1R, hindering the spread of osteosarcoma cells. This discovery opens exciting possibilities for new treatments that could significantly improve the lives of patients battling this aggressive cancer.

A Beacon of Hope for Osteosarcoma Patients

If these findings are further confirmed, aprepitant could offer a novel, safe, and readily available treatment option for osteosarcoma. It's like a oasis in the vast desert of cancer research, offering hope and a potential solution to this devastating disease.

Dr.Camel's Conclusion

Imagine a vast desert, and osteosarcoma is a relentless sandstorm threatening to engulf everything in its path. Aprepitant could be a sturdy wall, offering a line of defense against this formidable enemy. This research provides promising insights into the potential of aprepitant as a powerful weapon against osteosarcoma.

Date :
  1. Date Completed 2022-10-03
  2. Date Revised 2022-10-04
Further Info :

Pubmed ID

36177059

DOI: Digital Object Identifier

PMC9514929

Related Literature

Article Analysis
・Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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