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Antipsychotic Safety in Liver Disease: A Narrative Review and Practical Guide for the Clinician.

Author: DopheideJulie A, GuntherMatthew

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This narrative review evaluated the risk and types of liver injury associated with antipsychotic therapy. The review found that antipsychotic-induced liver dysfunction is uncommon to rare. Chlorpromazine, clozapine, and olanzapine pose the greatest risk of hepatoxicity, while quetiapine and risperidone pose a moderate risk. The review also provided recommendations for dose adjustments, monitoring, and patient counseling.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Clinicians treating psychiatric disorders in medically ill patients need a comprehensive resource for comparing the risk and types of liver injury associated with antipsychotic therapy. OBJECTIVE: We conducted a narrative review aimed at developing a comprehensive resource comparing ant...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaclp.2022.09.006

データ提供：米国国立医学図書館（NLM）

Antipsychotics and Liver Health: A Guide for Clinicians

This study provides a comprehensive review of the potential risks associated with antipsychotic medications in patients with liver disease. The authors compiled information from various sources to compare different antipsychotics based on their risk of inducing or worsening liver injuries. This review offers valuable guidance for clinicians managing psychiatric disorders in patients with liver disease.

Navigating the Risks of Antipsychotics in Liver Disease

The study highlights the importance of carefully considering the risk-benefit profile of antipsychotic medications in patients with liver disease. Some antipsychotics, such as chlorpromazine, clozapine, and olanzapine, pose a higher risk of hepatotoxicity compared to others. Clinicians must weigh the potential benefits of treating psychosis against the potential risks to liver health. It's like navigating a desert with various paths, each with its own risks and rewards.

Individualized Management of Antipsychotic Therapy

The study emphasizes the importance of individualizing antipsychotic therapy for patients with liver disease. This involves careful patient selection, dose adjustment, regular monitoring, and patient counseling. Clinicians should consider the patient's existing liver condition, the specific antipsychotic being prescribed, and the potential for side effects. Just like a desert traveler chooses the appropriate gear for their journey, clinicians must select and manage antipsychotic therapy with careful consideration.

Dr.Camel's Conclusion

This review provides valuable guidance for clinicians treating psychiatric disorders in patients with liver disease. It emphasizes the importance of careful risk-benefit analysis, individualized therapy, and ongoing monitoring. It's like a guidebook for traversing a complex and challenging desert, providing essential knowledge for navigating the risks and rewards of antipsychotic therapy in patients with liver disease.

Date :
  1. Date Completed 2023-02-14
  2. Date Revised 2023-05-24
Further Info :

Pubmed ID

36180017

DOI: Digital Object Identifier

10.1016/j.jaclp.2022.09.006

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English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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