Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis.

Author: KotaniTakuya, MatsudaShogo, SaitoTakashi, SatoTakako, SuzukaTakayasu, TakeuchiTohru

Paper Details 
Original Abstract of the Article :
Adipose-derived mesenchymal stem cells (ASCs) have gained attention as a new treatment for systemic sclerosis (SSc). Low-molecular-weight heparin (LMWH) enhances cell function and stimulates the production of hepatocyte growth factor (HGF) in a variety of cells. This study investigated the effects o...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9540693/

データ提供:米国国立医学図書館(NLM)

Adipose-Derived Mesenchymal Stem Cells: A Potential Therapy for Systemic Sclerosis

This research investigates the potential therapeutic benefits of adipose-derived mesenchymal stem cells (ASCs) for treating systemic sclerosis (SSc), an autoimmune disease characterized by excessive fibrosis. The study explores the impact of low-molecular-weight heparin (LMWH) on ASC function, specifically focusing on its ability to enhance cell migration and hepatocyte growth factor (HGF) secretion. The authors evaluate the therapeutic efficacy of LMWH-activated ASCs in a mouse model of SSc, providing valuable insights into the potential of this approach for treating SSc.

Unleashing the Potential of Stem Cells for SSc Treatment

This study provides promising evidence for the potential of LMWH-activated ASCs as a therapeutic strategy for treating SSc. The research suggests that LMWH treatment can enhance the therapeutic efficacy of ASCs by stimulating their migration and HGF secretion. These findings highlight the potential of ASCs, particularly those activated with LMWH, as a promising therapeutic option for patients with SSc.

Hope for SSc Patients: Exploring New Treatment Options

The research presents a ray of hope for SSc patients by exploring a new treatment option using LMWH-activated ASCs. The study's findings emphasize the importance of ongoing research to further understand the mechanisms behind SSc and develop more effective treatment strategies. This research serves as a reminder that even in the face of challenging diseases, there is always hope for new discoveries and therapeutic advancements.

Dr.Camel's Conclusion

This research, like a refreshing oasis in the desert, offers a promising new approach for treating SSc. The study's findings underscore the importance of stem cell therapies and the potential of LMWH to enhance their efficacy. This research provides hope for SSc patients and encourages continued exploration of novel treatment options.

Date :
  1. Date Completed 2022-10-11
  2. Date Revised 2022-11-09
Further Info :

Pubmed ID

36207753

DOI: Digital Object Identifier

PMC9540693

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Languages

English

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