Cognitive function with evolocumab in pediatric heterozygous familial hypercholesterolemia.

Author: BergeronJean, BridgesIan, GaudetDaniel, GaudetIsabelle, HamerAndrew, HovinghG Kees, KasteleinJohn J P, MachFrançois, MaruffPaul, PierreJulie St, RaalFrederick J, RuzzaAndrea, SantosRaul D, SchembriAdrian, WiegmanAlbert

Paper Details 
Original Abstract of the Article :
Evolocumab is a fully human monoclonal antibody inhibitor of PCSK9 approved for lowering low-density lipoprotein cholesterol in adults and pediatric patients with familial hypercholesterolemia (FH). The cognitive safety of evolocumab has been established in adults but has not yet been described in p...See full text at original site
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引用元:
https://doi.org/10.1016/j.jacl.2022.07.005

データ提供:米国国立医学図書館(NLM)

Evolocumab and Cognitive Function in Children: A New Frontier

This [clinical trial] explores the cognitive safety of evolocumab, a PCSK9 inhibitor used to treat familial hypercholesterolemia (FH), in pediatric patients. The authors point out that the cognitive safety of evolocumab has been established in adults, but [further investigation] is needed for children. This research is particularly relevant as it delves into the [uncharted territory] of [pediatric drug safety].

A Call for Further Research on Pediatric Drug Safety

This research highlights the importance of [evaluating the safety] of [medications] in children. While evolocumab has demonstrated effectiveness in lowering cholesterol in adults, its effects on children's cognitive functions remain unexplored. This calls for further investigation and emphasizes the need to understand the [specific needs] of pediatric patients when prescribing medications.

Navigating the [Diverse Needs] of Pediatric Patients

Understanding the cognitive safety of medications in children is crucial. While we often think of medicine as a [universal solution], it's important to remember that children's bodies are still developing, and their responses to medications can differ greatly from adults. This research serves as a reminder to approach [pediatric care] with [caution] and a strong focus on [individualized treatment].

Dr. Camel's Conclusion

This research sheds light on the importance of [drug safety] in children. Just like a camel adapts to the harsh desert conditions, children need tailored care that considers their unique developmental stages. This study urges for more [thorough investigation] to ensure the well-being of our youngest patients. By understanding the specific effects of medications in children, we can provide safer and more effective treatments.
Date :
  1. Date Completed 2022-11-15
  2. Date Revised 2022-11-28
Further Info :

Pubmed ID

36210291

DOI: Digital Object Identifier

10.1016/j.jacl.2022.07.005

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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