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Overlooked switch from transient sedation to sustained excitement in the Biphasic effects of Ephedra Herb extract administered orally to mice.
Author: AmakuraYoshiaki, GodaYukihiro, HakamatsukaTakashi, HanawaToshihiko, HuangXuedan, HyugaMasashi, HyugaSumiko, KobayashiYoshinori, OdaguchiHiroshi, UchiyamaNahoko
Original Abstract of the Article :
In our previous study, we reported that Ephedra Herb extract (EHE) increased the locomotor activity of mice in the open-field test and reduced the immobility time in the forced swim test. Ephedrine alkaloids (EAs) are thought to be responsible for the adverse effects of Ephedra Herb. However, there ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/j.jep.2022.115827
データ提供:米国国立医学図書館(NLM)
The Ephedra Herb: A Journey from Sedation to Excitement
Ephedra herb extract (EHE) is a popular ingredient in traditional medicine, but its effects on the nervous system can be unpredictable. This study delves into the biphasic effects of EHE, exploring the intriguing switch from transient sedation to sustained excitement observed in mice. Ephedrine alkaloids (EAs) are known to be responsible for the adverse effects of Ephedra Herb, but the researchers wanted to investigate whether the amount of EAs in the herb actually triggers these effects. Their research focused on the time course analysis of the open-field test, a standard test used to assess locomotor activity in rodents.
Their analysis revealed a fascinating pattern: EHE initially induced a state of sedation in the mice, which transitioned into sustained excitement over time. This observation prompts further investigation into the mechanisms behind this biphasic effect and the role of EAs in this intriguing transition. It also raises questions about the safety of EHE, particularly when used in formulations that do not control the dosage and composition of the herb.
The Desert of Uncertainty about Ephedra Herb
This study presents a complex picture of EHE's effects, highlighting the need for cautious use and further research. Understanding the mechanisms behind the biphasic effect of EHE is crucial to ensure its safe and effective use.
A Journey Towards Understanding Ephedra Herb
This study serves as a reminder that natural remedies are not always benign. The potential for unexpected or adverse effects, even from seemingly natural substances, should be considered. Further research into the safety and efficacy of EHE is critical to ensure that it can be used safely and effectively.
Dr.Camel's Conclusion
This study reveals the unpredictable nature of EHE, demonstrating a complex transition from sedation to excitement. Further research is necessary to understand the mechanisms underlying these biphasic effects and to ensure the safe and effective use of EHE. This research serves as a reminder that even natural substances can have surprising effects and require careful consideration.
Date :
- Date Completed 2022-11-08
- Date Revised 2022-11-08
Further Info :
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