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Real life evaluation of the multi-organ effects of Lumacaftor/Ivacaftor on F508del homozygous cystic fibrosis patients.
Author: IlivitzkiAnat, KhatibMohamed, KorenIlana, LivnatGalit, SchnappZeev, ShorbajiNadeem, ShteinbergMichal, Yaacoby-BianuKarin
Original Abstract of the Article :
Lumacaftor/Ivacaftor (LUM-IVA), a cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector-potentiator combination, improves lung function and reduces pulmonary exacerbations (PEx) in F508del homozygous CF patients. However, the systemic effects of LUM-IVA outside the respiratory...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585743/
データ提供:米国国立医学図書館(NLM)
Lumacaftor/Ivacaftor: A Multi-Organ Journey for Cystic Fibrosis
The world of [cystic fibrosis (CF)] is a challenging landscape, where a faulty gene disrupts the delicate balance of the body. This study, like a seasoned explorer venturing into uncharted territory, investigates the multi-organ effects of [lumacaftor/ivacaftor (LUM-IVA)] in patients with [F508del homozygous CF]. Researchers analyzed the impact of this medication on [lung function, pulmonary exacerbations (PEx), and other organ systems].
Beyond the Lungs: A Comprehensive View
The study confirms that [LUM-IVA] effectively improves [lung function] and reduces [PEx] in patients with [F508del homozygous CF]. However, the findings also shed light on the [systemic effects] of [LUM-IVA] beyond the respiratory system, highlighting the importance of considering its impact on other organs.
Navigating the Complexities of Cystic Fibrosis
This study provides valuable insights into the multifaceted nature of [CF] and the importance of understanding the broader implications of treatment interventions. It emphasizes the need for a comprehensive approach that considers the impact of medication on multiple organ systems. Navigating the complexities of [CF] requires ongoing research and clinical vigilance to ensure optimal patient outcomes.
Dr. Camel's Conclusion
This study offers a comprehensive look at the multi-organ effects of lumacaftor/ivacaftor in patients with F508del homozygous cystic fibrosis. While it confirms its beneficial impact on lung function, it also highlights the importance of considering its systemic effects on other organs. This underscores the need for ongoing research and careful monitoring to ensure the long-term safety and efficacy of this medication.
Date :
- Date Completed 2022-10-25
- Date Revised 2022-10-31
Further Info :
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