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Efficacy and safety of finerenone in chronic kidney disease associated with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trials.
Author: BaoWujisiguleng, LiNing, SunLuying, YaoZhi, ZhangMingzhu
Original Abstract of the Article :
PURPOSE: The main objective was to evaluate the clinical efficacy and safety of finerenone in patients with CKD associated with T2D, especially with regard to renal and cardiovascular protection. METHODS: Eight databases were searched. Mean difference (MD) with 95% confidence interval (CI) of the o...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s00228-022-03408-w
データ提供:米国国立医学図書館(NLM)
Finerenone: A Refreshing Oasis for Chronic Kidney Disease
The desert of chronic kidney disease (CKD) can be a harsh and unforgiving environment, where patients face a constant battle against declining kidney function. This research explores the potential of finerenone, a novel medication, to offer a refreshing oasis for patients with CKD associated with type 2 diabetes. Using a systematic review and meta-analysis of randomized clinical trials, the researchers meticulously analyzed the efficacy and safety of finerenone in this patient population.
Finerenone: A Hopeful Beacon in the Desert
The results, like an oasis shimmering in the distance, show that finerenone significantly reduced urinary albumin-to-creatinine ratio, a key indicator of kidney damage, and lowered the risk of both kidney disease progression and cardiovascular events. This finding is a beacon of hope for patients, offering the promise of slowing disease progression and improving overall health.
Finerenone: Navigating the Desert with Caution
While finerenone demonstrated significant benefits, it's important to note that it can increase serum potassium levels and the risk of hyperkalemia. This highlights the need for careful monitoring and potential adjustments in therapy. Like a desert traveler, we must approach this new treatment with caution, ensuring we are well-prepared for any unforeseen challenges.
Dr.Camel's Conclusion
Finerenone holds promise as a potential treatment for CKD associated with type 2 diabetes. Its ability to slow kidney disease progression and reduce cardiovascular risk is encouraging. However, we must remain mindful of potential side effects and prioritize careful patient monitoring. The desert of CKD is vast, and we must navigate it with caution and hope.
Date :
- Date Completed 2022-11-14
- Date Revised 2022-11-14
Further Info :
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English
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