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The Optimization and Evaluation of Flibanserin Fast-Dissolving Oral Films.

Author: AlghaithAdel F, AlhamedAbdullah S, AlmutairiMohammed M, AlqinyahMohammed, MahrousGamal M, ShazlyGamal A, SyedSaeed A, ZidanDiaa Eldin Z

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed a fast-dissolving oral film for flibanserin, a drug used to treat hypoactive sexual desire disorder. The film formulation, incorporating beta hydroxypropyl cyclodextrin-FLB inclusion complex, improved the solubility and dissolution rate of flibanserin, potentially leading to faster onset of action and better bioavailability.
Paper Details　
Original Abstract of the Article :
Flibanserin (FLB) is a drug used for female hypotensive sexual desire disorder approved by the FDA in August 2015. FLB exhibits extensive hepatic first-pass metabolism and low aqueous solubility, hence poor oral bioavailability. In this study, beta hydroxypropyl cyclodextrin-FLB inclusion complexes ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609929/

データ提供：米国国立医学図書館（NLM）

Optimizing Flibanserin Delivery: A New Approach for Fast-Dissolving Oral Films

This study ventures into the realm of drug delivery, exploring innovative approaches to improve the bioavailability and efficacy of flibanserin (FLB), a medication used to treat female hypoactive sexual desire disorder. The research focuses on developing fast-dissolving oral films incorporating FLB inclusion complexes, aiming to enhance drug solubility and absorption.

A New Frontier in Drug Delivery: Unlocking the Potential of FLB

The study successfully developed fast-dissolving oral films containing FLB inclusion complexes, which significantly improved the drug's aqueous solubility and dissolution rate. This innovative formulation has the potential to overcome the challenges associated with FLB's low oral bioavailability and provide a faster onset of action.

Revolutionizing Treatment: Empowering Patients with Better Options

The development of these fast-dissolving oral films offers a promising new approach to administering FLB, potentially improving treatment efficacy and enhancing patient experience. This research underscores the importance of continued innovation in drug delivery to optimize therapeutic outcomes and address unmet needs in healthcare.

Dr.Camel's Conclusion

Imagine a desert where the sun scorches the land, making it difficult to absorb the vital nutrients needed for growth. This study, like a refreshing oasis, reveals a novel approach to drug delivery, unlocking the potential of flibanserin by enhancing its solubility and absorption. This research represents a significant step forward, offering a more effective and convenient option for patients seeking treatment.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-10-30
Further Info :

Pubmed ID

36297875

DOI: Digital Object Identifier

PMC9609929

Related Literature

Article Analysis
・Effects of flibanserin
SNS
PICO Info
in preparation
Languages

English

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