Paper Details

  1. Home
  2. Paper Details

Ertapenem-induced neurotoxicity in an end-stage renal disease patient on intermittent haemodialysis: a case report.

Author: ArimuthuDurga A, MazlanSadanah Aqashiah, ShaharShamira

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Carbapenem-induced neurotoxicity is an unusual side effect, with seizure being the most common symptom. Imipenem-cilastin is associated with the most severe neurotoxicity, and dose adjustment is necessary for patients with chronic kidney disease (CKD). Ertapenem-associated neurotoxicity is increasingly reported in CKD patients, but it is less common with recommended dose adjustments.
Paper Details　
Original Abstract of the Article :
Carbapenem-induced neurotoxicity is an unusual side effect, with seizure being the most commonly reported symptom. Among the carbapenems, imipenem-cilastin is classically associated with the most severe neurotoxicity side effects. Carbapenem is mainly excreted by the kidney and its half-life is sign...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644511/

データ提供：米国国立医学図書館（NLM）

The Curious Case of Ertapenem-Induced Neurotoxicity

This study presents a fascinating case report of a patient with end-stage renal disease who experienced neurotoxicity after receiving ertapenem, a type of antibiotic. This case highlights the importance of careful dose adjustment for medications in patients with kidney disease, as they are more susceptible to side effects due to impaired drug clearance.

Navigating the Risks of Carbapenems in Kidney Disease

The study emphasizes the unique challenges faced by patients with kidney disease when receiving carbapenem antibiotics. These drugs are primarily excreted by the kidneys, so impaired kidney function can lead to prolonged drug exposure and an increased risk of side effects, including neurotoxicity. This case report serves as a reminder for clinicians to be vigilant in monitoring patients with kidney disease receiving carbapenem antibiotics.

The Importance of Personalized Medicine

This study highlights the importance of personalized medicine, which focuses on tailoring treatments to individual patients based on their specific needs and characteristics. In this case, the patient's kidney disease required a careful adjustment of the ertapenem dose to minimize the risk of neurotoxicity. This research underscores the need for a personalized approach to medication management, especially in patients with underlying health conditions.

Dr. Camel's Conclusion

This case report is a compelling reminder that even seemingly routine medical interventions can have unexpected consequences, particularly in patients with underlying health conditions. The study underscores the importance of careful monitoring and personalized care to ensure patient safety and minimize the risks of potential side effects.

Date :
  1. Date Completed 2022-11-10
  2. Date Revised 2022-11-16
Further Info :

Pubmed ID

36348388

DOI: Digital Object Identifier

PMC9644511

Related Literature

Article Analysis
・Side Effects of imipenem
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.