Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial.

Author: , BakrisGeorge L, BelletMarc, DanaietashParisa, DreierRoland F, FlackJohn M, HaskellLloyd P, NarkiewiczKrzysztof, Sassi-SayadiMouna, SchlaichMarkus P, WangJi-Guang, WeberMichael A

Paper Details 
Original Abstract of the Article :
Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs...See full text at original site
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引用元:
https://doi.org/10.1016/S0140-6736(22)02034-7

データ提供:米国国立医学図書館(NLM)

A Novel Approach: Approcitentan for Resistant Hypertension

This research tackles the challenging world of [resistant hypertension], a condition where [blood pressure remains high] despite multiple medications. The study investigates the potential benefits of [aprocitentan], a novel drug that targets the [endothelin pathway]. This approach explores a new avenue for managing this complex and often difficult-to-treat condition.

The Endothelin Pathway: A New Target for Hypertension Control

This research highlights the potential of [targeting the endothelin pathway] as a strategy for [managing resistant hypertension]. The study findings suggest that [aprocitentan] may offer a promising treatment option for patients who haven't responded to conventional therapies, potentially leading to [improved blood pressure control] and a reduction in [cardiovascular risk].

Living with High Blood Pressure: A Quest for Control

This research offers a ray of hope for individuals navigating the desert of [resistant hypertension]. It suggests that [new treatment options] are emerging, offering greater potential for [controlling blood pressure] and reducing the long-term risks associated with this condition. Like a camel traversing the desert, we can persevere in our pursuit of good health, seeking new solutions to overcome challenges.

Dr.Camel's Conclusion

This research is like a desert caravan, bringing new hope and possibilities for individuals facing the challenges of resistant hypertension. The study highlights the potential of aprocitentan to offer a novel and effective treatment strategy, potentially leading to improved blood pressure control and reducing cardiovascular risk. By embracing innovation and collaborating with healthcare providers, we can journey towards a healthier future.
Date :
  1. Date Completed 2022-12-12
  2. Date Revised 2023-11-22
Further Info :

Pubmed ID

36356632

DOI: Digital Object Identifier

10.1016/S0140-6736(22)02034-7

Related Literature

SNS
PICO Info
in preparation
Languages

English

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