Virological outcomes and metabolic effects after switching from ritonavir-boosted protease inhibitors to a dolutegravir-based regimen in virologically suppressed patients living with HIV.

Author: ChetchotisakdPloenchan, MeesingAtibordee, NuntawitTharatorn, SribenjaluxWantin

Paper Details 
Original Abstract of the Article :
A ritonavir-boosted protease inhibitor (PI)-based antiretroviral therapy (ART) regimen can cause abnormal lipid levels and increased incidence of cardiovascular disease. Switching to a dolutegravir (DTG)-based regimen has been shown to improve blood lipid levels, but data in the Thai population are ...See full text at original site
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引用元:
https://doi.org/10.1177/09564624221137972

データ提供:米国国立医学図書館(NLM)

Switching Gears: A Look at Dolutegravir-Based Regimens for HIV Patients

In the vast desert of HIV research, we're always searching for new ways to help patients thrive. This study delves into the world of antiretroviral therapy (ART), focusing on the potential benefits of switching from ritonavir-boosted protease inhibitors (PIs) to a dolutegravir (DTG)-based regimen for patients already successfully managing their HIV. This switch has been shown to be a welcome oasis in the desert, offering improved blood lipid levels, which is vital for long-term health. While this research is crucial for the Thai population, it's a reminder that understanding the impact of these changes is a journey with many miles ahead.

Dolutegravir: A Potential Solution for Lipid Levels

This research suggests that switching to a DTG-based regimen could offer an oasis in the desert for many HIV patients. The study found that this switch can lead to better lipid levels, which can have a positive impact on their overall health and well-being. This discovery is crucial for patients in Thailand, where there is a limited amount of data on this topic. As we journey through the desert of research, this study provides a valuable roadmap for future studies and clinical applications.

A New Hope for Better Cardiovascular Health

The researchers are cautiously optimistic about the potential of DTG-based regimens. Switching to this new approach may be a way to improve cardiovascular health for many patients living with HIV. Like a camel navigating a sandstorm, it's important to continue observing and analyzing the long-term effects of this switch. This research is a promising sign that we're moving towards a healthier future for patients battling HIV.

Dr.Camel's Conclusion

The switch from ritonavir-boosted PI-based ART regimens to dolutegravir-based regimens shows promise for improving lipid levels and potentially enhancing cardiovascular health in HIV patients. While this research is focused on the Thai population, its implications for the global HIV community are vast. It's a crucial reminder that continuous research and exploration are essential to guide us through the ever-changing landscape of HIV treatment.
Date :
  1. Date Completed 2023-01-20
  2. Date Revised 2023-02-23
Further Info :

Pubmed ID

36378013

DOI: Digital Object Identifier

10.1177/09564624221137972

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SNS
PICO Info
in preparation
Languages

English

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