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Thrombocytopenia limits the feasibility of salvage lomustine chemotherapy in recurrent glioblastoma: a secondary analysis of EORTC 26101.

Author: BrandesAlba A, ClementPaul M, GolfinopoulosVassilis, GorliaThierry, IdbaihAhmed, Le RhunEmilie, OppongFelix Boakye, PlattenMichael, PreusserMatthias, TaphoornMartin Jb, WellerMichael, WickWolfgang, van den BentMartin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Thrombocytopenia was the leading cause of dose modification for lomustine chemotherapy in recurrent glioblastoma. Dose modification due to thrombocytopenia was associated with inferior progression-free survival and overall survival in patients with MGMT promoter-methylated tumors.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Thrombocytopenia represents the main cause of stopping alkylating chemotherapy for toxicity. Here, we explored the incidence, and the consequences for treatment exposure and survival, of thrombocytopenia induced by lomustine in recurrent glioblastoma. METHODS: We performed a retrospecti...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejca.2022.10.006

データ提供：米国国立医学図書館（NLM）

Thrombocytopenia: A Hidden Obstacle in Glioblastoma Treatment

Glioblastoma, a type of brain tumor, is a challenging condition that can feel like navigating a desert of uncertainty. This study explores the impact of thrombocytopenia, a condition characterized by low platelet count, on the treatment of recurrent glioblastoma. The researchers are searching for ways to overcome the obstacles that can hinder treatment effectiveness, much like finding a way to cross a treacherous desert canyon.

The study found that thrombocytopenia is a significant obstacle in the treatment of recurrent glioblastoma. It's like encountering a hidden canyon that blocks the path forward. The researchers also found that thrombocytopenia can lead to treatment delays and dose reductions, ultimately affecting the effectiveness of treatment.

Overcoming the Canyon: Managing Thrombocytopenia in Glioblastoma

This research highlights the importance of managing thrombocytopenia in patients with recurrent glioblastoma. It's like finding a way to cross a treacherous canyon, ensuring a safe and effective passage through the desert of treatment.

The study emphasizes the need for strategies to mitigate thrombocytopenia, allowing for better treatment delivery and improving outcomes for patients. It's like finding a hidden bridge that allows for a smoother journey through the desert, leading to greater chances of success.

Dr.Camel's Conclusion

This study shines a light on the challenges of thrombocytopenia in recurrent glioblastoma treatment. It's like encountering a hidden canyon that can hinder progress. The researchers are working to find ways to overcome this obstacle, paving the way for more effective treatment and improved outcomes for these patients.

Date :
  1. Date Completed 2022-12-23
  2. Date Revised 2023-03-13
Further Info :

Pubmed ID

36379185

DOI: Digital Object Identifier

10.1016/j.ejca.2022.10.006

Related Literature

Article Analysis
・Effects of lomustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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