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Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia.

Author: BaeKi Hyun, ChanKiat Hwa, ChenQingfeng, HerZhisheng, KurisawaMotoichi, LaiFritz, MongJamie, Niibori-NambuAkiko, OsatoMotomi, TanMin-Han

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A bone marrow-targetable green tea catechin-based micellar nanocomplex was found to synergistically amplify the anti-leukemic potency of sorafenib via selective disruption of pro-survival mTOR signaling. The nanocomplex demonstrated greater bone marrow accumulation compared to free sorafenib, leading to effective eradication of bone marrow-residing leukemic blasts and improved survival rates in an AML patient-derived xenograft (AML-PDX) mouse model.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Currently available anti-leukemia drugs have shown limited success in the treatment of acute myeloid leukemia (AML) due to their poor access to bone marrow niche supporting leukemic cell proliferation. RESULTS: Herein, we report a bone marrow-targetable green tea catechin-based micellar...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670631/

データ提供：米国国立医学図書館（NLM）

Targeting the Bone Marrow Niche in Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is a challenging cancer to treat, and current therapies often struggle to reach the bone marrow niche where leukemic cells proliferate. This study presents a novel approach to AML treatment by developing a bone marrow-targetable nanocomplex loaded with green tea catechin and sorafenib.

A Synergistic Approach to AML Treatment

The researchers found that this nanocomplex effectively delivers the therapeutic agents to the bone marrow, targeting the leukemic cells residing in this crucial niche. The study highlights the potential of this nanocomplex to enhance the efficacy of AML therapies, leading to improved outcomes.

Hope for a More Effective Treatment of AML

This research offers a ray of hope for patients with AML. The development of bone marrow-targeted therapies represents a significant advancement in the treatment of this challenging cancer, potentially leading to improved survival rates and reduced side effects.

Dr.Camel's Conclusion

This study is like a resourceful desert traveler, finding a new way to reach a vital destination. By targeting the bone marrow niche, this nanocomplex offers a promising new strategy for combating AML, reminding us of the power of innovation in the fight against cancer.

Date :
  1. Date Completed 2022-11-21
  2. Date Revised 2022-11-21
Further Info :

Pubmed ID

36384529

DOI: Digital Object Identifier

PMC9670631

Related Literature

Article Analysis
・Effective treatment of bone marrow diseases
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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