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S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT<sub>1A</sub> receptors.

Author: CrestaniCarlos C, GuimarãesFrancisco S, JocaSâmia Rl, MacielIzaque S, SalesAmanda J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the antidepressant effects of S-adenosyl-l-methionine (SAMe) in mice. SAMe reduced immobility time in the forced swimming test, an effect that was blocked by inhibiting serotonin synthesis or blocking 5-HT1A receptors. These findings suggest that the antidepressant-like effects of SAMe are dependent on serotonin synthesis and 5-HT1A receptor activation.
Paper Details　
Original Abstract of the Article :
S-adenosyl-l-methionine (SAMe), a methyl donor, induces antidepressant effects in preclinical and clinical studies of depression. However, the mechanisms behind these effects have been poorly investigated. Since SAMe is involved in monoamine metabolism, this work aimed at 1) testing the effects indu...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuint.2022.105442

データ提供：米国国立医学図書館（NLM）

S-adenosyl-l-methionine's Antidepressant Effects: A Role for 5-HT1A Receptors

This study explores the fascinating world of neuropharmacology, investigating the antidepressant effects of S-adenosyl-l-methionine (SAMe) and the potential mechanisms underlying its action. Researchers conducted a series of experiments to evaluate the antidepressant-like effects of SAMe in mice and explore the involvement of serotonergic neurotransmission, specifically the 5-HT1A receptors, in mediating these effects.

SAMe: A Promising Antidepressant with Potential for 5-HT1A Receptor Modulation

The study demonstrated that SAMe exhibited antidepressant-like effects in mice, reducing immobility time in behavioral tests. Further investigation revealed that these effects were dependent on serotonin synthesis and activation of 5-HT1A receptors. This suggests that SAMe's antidepressant-like effects may be mediated through its influence on serotonergic neurotransmission, specifically through the activation of 5-HT1A receptors.

Understanding the Brain's Chemistry

This study provides valuable insights into the mechanisms underlying antidepressant effects. It highlights the importance of serotonin and 5-HT1A receptors in regulating mood and offers potential targets for the development of new antidepressant therapies. Just as a desert oasis provides a haven for weary travelers, understanding the brain's chemical pathways can lead to new treatments for mental health conditions.

Dr.Camel's Conclusion

This research sheds light on the potential of SAMe as a promising antidepressant, highlighting its role in modulating serotonergic neurotransmission. It's a reminder that understanding the complex chemistry of the brain can lead to breakthroughs in treating mental health conditions. This study is a step forward in our journey to find effective and safe solutions for those struggling with depression.

Date :
  1. Date Completed 2023-01-10
  2. Date Revised 2023-02-11
Further Info :

Pubmed ID

36402294

DOI: Digital Object Identifier

10.1016/j.neuint.2022.105442

SNS
PICO Info
in preparation
Languages

English

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