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Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors.

Author: AndersonMatthew I, ArnoldRebecca C, BonannoShivan L, DonleaJeffrey M, KaiserAndrea, KnappElizabeth M, KrantzDavid E, RuppertManuela, SampsonMaureen M, ScholzHenrike, XuLi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the role of the serotonin transporter (SERT) in regulating sleep and other behaviors in Drosophila melanogaster. Newly generated dSERT mutants exhibited increased total sleep and altered sleep architecture, similar to the effects of the SSRI citalopram. The study also revealed potential distinct serotonergic circuits modulating daytime versus nighttime sleep. dSERT mutants also showed defects in copulation and food intake, suggesting that serotonin plays a multifaceted role in regulating diverse behaviors in D. melanogaster.
Paper Details　
Original Abstract of the Article :
The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. The mechanisms by which inhibition of SERT activity influences behavior are poorly understood. To address this question in the model organism Drosophila melanog...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9721485/

データ提供：米国国立医学図書館（NLM）

Serotonin Transporter: A Key Player in Sleep, Courtship, and Feeding

The field of [neurobiology] seeks to understand the complex mechanisms underlying behavior. This study investigates the role of the [serotonin transporter (SERT)] in regulating various behaviors in the model organism [Drosophila melanogaster]. The researchers generated new [loss-of-function mutations] in Drosophila SERT (dSERT) and found that these mutations impacted [sleep, courtship, and feeding behaviors]. These findings provide insights into the multifaceted role of serotonin in regulating complex behaviors.

Serotonin Transporter: A Multifaceted Regulator of Behavior

This research highlights the crucial role of the [serotonin transporter] in regulating a range of behaviors, including [sleep, courtship, and feeding]. The study's findings demonstrate that alterations in SERT function can significantly impact these complex behaviors. This underscores the importance of understanding the role of serotonin in modulating various aspects of our lives.

Unlocking the Secrets of Serotonin

This study contributes to our understanding of the [neurochemical basis of behavior]. The researchers' findings provide valuable insights into the role of serotonin in regulating various aspects of our lives, from [sleep] and [courtship] to [feeding]. This knowledge is crucial for advancing our understanding of the brain and its complex functions.

Dr. Camel's Conclusion

This research unveils the fascinating and complex role of the serotonin transporter in the desert of behavioral regulation. Like the shifting dunes of a desert landscape, serotonin's influence on our behaviors is multifaceted and dynamic. This study encourages us to further explore the intricate interplay of neurochemicals and their impact on our lives.

Date :
  1. Date Completed 2022-12-07
  2. Date Revised 2022-12-15
Further Info :

Pubmed ID

36409783

DOI: Digital Object Identifier

PMC9721485

Related Literature

Article Analysis
・Side Effects of citalopram
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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