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In Vitro and Ex Vivo Evaluation of Fluocinolone Acetonide-Acitretin-Coloaded Nanostructured Lipid Carriers for Topical Treatment of Psoriasis.
Author: Al HawajMaitham A, AliZakir, AlsalmanAbdulkhaliq J, FaridArshad, HussainAbid, KhanAtif Ullah, MahmoodSaima, MohainiMohammed Al, RajputIrfa Basharat, RazaHassan, ShahKifayat Ullah, ShahShefaat Ullah
Original Abstract of the Article :
Psoriasis is chronic autoimmune disease that affects 2-5% of the global population. Fluocinolone acetonide (FLU) and acitretin (ACT) are widely used antipsoriatic drugs that belong to BCS classes II and IV, respectively. FLU exhibits side effects, such as skin irritation and a burning sensation. ACT...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689900/
データ提供：米国国立医学図書館（NLM）
A New Approach to Topical Treatment of Psoriasis: Fluocinolone Acetonide-Acitretin-Coloaded Nanostructured Lipid Carriers
Psoriasis, a chronic inflammatory skin condition, can be a real nuisance. This study presents a novel approach to treating psoriasis, focusing on a topical formulation of Fluocinolone acetonide (FLU) and acitretin (ACT), two widely used antipsoriatic drugs. Researchers developed nanostructured lipid carriers (NLCs) to deliver FLU and ACT effectively and minimize side effects. By employing a modified microemulsion method, they successfully fabricated FLU-ACT-coloaded NLCs and optimized their formulation based on particle size, zeta potential, and encapsulation efficiency. The optimized NLCs were then incorporated into a gel for topical application. In vitro and ex vivo studies confirmed the sustained release of FLU and ACT from the NLC gel, suggesting enhanced drug delivery and potentially improved therapeutic efficacy.
The Potential of Nanostructured Lipid Carriers for Topical Drug Delivery
This study highlights the potential of nanostructured lipid carriers as a promising delivery system for topical drugs. NLCs offer several advantages, including enhanced drug encapsulation, controlled release, and improved skin penetration. This research demonstrates the potential of NLCs for developing more effective and patient-friendly topical treatments for psoriasis and other skin conditions.
The Importance of Minimizing Side Effects in Topical Drug Delivery
The study's findings underscore the importance of minimizing side effects associated with topical drug delivery. By encapsulating FLU and ACT in NLCs, researchers aimed to reduce skin irritation and other adverse effects associated with conventional topical formulations. This research highlights the ongoing need for innovative drug delivery systems that can enhance therapeutic efficacy while minimizing side effects.
Dr. Camel's Conclusion
Just like a camel traversing a vast desert, the search for effective and safe topical treatments for psoriasis is an ongoing journey. This study presents a promising oasis, highlighting the potential of FLU-ACT-coloaded NLCs as a novel approach to treating psoriasis. By harnessing the power of nanotechnology, we can potentially revolutionize topical drug delivery, offering patients more effective and tolerable treatment options.
Date :
- Date Completed n.d.
- Date Revised 2022-11-26
Further Info :
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