Topical Delivery of Hedgehog Inhibitors: Current Status and Perspectives.

Author: HædersdalMerete, Høyer-HansenMaria Helena, LitmanThomas, OlesenUffe Høgh, PedersenKristian Kåber

Paper Details 
Original Abstract of the Article :
Systemic treatment with hedgehog inhibitors (HHis) is available to treat basal cell carcinomas but their utility is limited by adverse effects. Topical delivery methods may reduce adverse effects, but successful topical treatment depends on sufficient skin uptake, biological response, and time in tu...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692957/

データ提供:米国国立医学図書館(NLM)

Topical Hedgehog Inhibitors for Basal Cell Carcinoma: A New Path for Treatment

Basal cell carcinoma (BCC), a common type of skin cancer, often requires treatment. This study examines the potential of topical hedgehog inhibitors (HHIs) as an alternative approach to treating BCC. The researchers reviewed both preclinical and clinical studies investigating the effectiveness and safety of topical HHIs, hoping to explore a less invasive and potentially more tolerable treatment option.

A New Frontier in BCC Treatment: Exploring Topical Hedgehog Inhibitors

The study suggests that topical HHIs hold promise for treating BCC. While preclinical studies have demonstrated the potential for effective drug delivery and biological response, clinical trials have shown mixed results. The researchers highlight the need for further investigation into the optimal formulations and delivery techniques to enhance the effectiveness of topical HHIs.

Navigating the Landscape of BCC Treatment: Finding the Right Path

This research offers a glimpse into the future of BCC treatment, while acknowledging the need for further research and optimization. The study emphasizes the importance of exploring alternative treatment options, particularly those that minimize side effects and improve patient quality of life.

Dr.Camel's Conclusion

The search for effective and tolerable treatments for BCC, like a quest for a hidden oasis in a vast desert, continues. This study provides a promising direction for exploration, reminding us that with perseverance and innovation, we can find new solutions to challenging medical problems.

Date :
  1. Date Completed 2022-12-06
  2. Date Revised 2022-12-13
Further Info :

Pubmed ID

36430669

DOI: Digital Object Identifier

PMC9692957

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.