Paper Details

  1. Home
  2. Paper Details

Real-life efficacy and safety of elexacaftor/tezacaftor/ivacaftor on severe cystic fibrosis lung disease patients.

Author: , AltenburgJosje, BosLieuwe D, BrinkmanPaul, FennDominic W, HaarmanEric G, KosRenate, LubRianne, Maitland-van der ZeeAnke H, MajoorChristof J, NeerincxAnne H, ReijersMonique H, RoukemaJolt, Terheggen-LagroSuzanne W J, VonkSteffie E M

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the safety and efficacy of elexacaftor/tezacaftor/ivacaftor in patients with severe cystic fibrosis lung disease in a real-life setting, finding improved lung function, BMI, and reduced exacerbations with only mild side effects.
Paper Details　
Original Abstract of the Article :
Elexacaftor/tezacaftor/ivacaftor (ETI) is a cystic fibrosis (CF) transmembrane conductance regulator modulator, which has shown efficacy in CF patients (≥6 years) with ≥1 Phe508del mutation and a minimal function mutation. In October 2019, ETI became available on compassionate use ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9703582/

データ提供：米国国立医学図書館（NLM）

Elexacaftor/Tezacaftor/Ivacaftor: A New Hope for Severe Cystic Fibrosis

The [Treatment of cystic fibrosis (CF)] is a complex and challenging area of [Medicine]. This research explores the [Real-life efficacy and safety] of [Elexacaftor/tezacaftor/ivacaftor (ETI)] in patients with [Severe CF lung disease]. This [Multicenter longitudinal observational study] aimed to assess the [Impact of ETI] on [Lung function, BMI, and exacerbations]. The study found that [ETI] led to [Significant improvement] in [Lung function and BMI], and a [Reduction in exacerbations]. This study provides [Encouraging evidence] for the [Effectiveness and safety] of [ETI] in [Managing severe CF lung disease].

A New Oasis in the Desert of Cystic Fibrosis Treatment

This study is a [Ray of hope] in the [Desert of cystic fibrosis]. The researchers have shown that [ETI] can [Improve lung function, increase BMI, and reduce exacerbations] in patients with [Severe CF lung disease]. This [Real-life evidence] is a [Significant step forward] in [Managing this complex condition] and [Improving the lives] of individuals with [CF].

Living with Cystic Fibrosis: A Journey of Hope

This research reminds us that [Cystic fibrosis] is a [Challenging condition] but [Advances in treatment] are constantly [Improving outcomes]. This study offers a [Promising new treatment] for individuals with [Severe CF lung disease], but [Further research] is needed to [Optimize treatment strategies] and [Ensure long-term efficacy and safety].

Dr.Camel's Conclusion

This observational study provides real-world evidence of the effectiveness and safety of elexacaftor/tezacaftor/ivacaftor in treating severe cystic fibrosis lung disease, offering hope for individuals living with this complex condition. The study highlights the importance of continued research to optimize treatment strategies and ensure long-term health outcomes for CF patients.

Date :
  1. Date Completed 2022-11-29
  2. Date Revised 2023-11-06
Further Info :

Pubmed ID

36440690

DOI: Digital Object Identifier

PMC9703582

Related Literature

Article Analysis
・Side Effects of tezacaftor and ivacaftor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.