Trabectedin impairs invasiveness and metastasis in adrenocortical carcinoma preclinical models.

Author: AbateAndrea, BasnetRam Manohar, BerrutiAlfredo, CosentiniDeborah, GianoncelliAlessandra, GrisantiSalvatore, HantelConstanze, LaganàMarta, MemoMaurizio, RibaudoGiovanni, RossiniElisa, SigalaSandra, TamburelloMariangela, TiberioGuido Alberto Massimo

Paper Details 
Original Abstract of the Article :
The pharmacological approach to adrenocortical carcinoma (ACC) is based on mitotane with/without etoposide, doxorubicin, and cisplatin, according to the disease stage. Considering the limited efficacy and toxicity of this treatment, new strategies are required. Trabectedin is a marine-derivated anti...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/36449565

データ提供:米国国立医学図書館(NLM)

Trabectedin: A Potential Oasis in the Desert of Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC), a rare and aggressive form of cancer, can feel like an unyielding desert, with limited treatment options and a high risk of metastasis. This research, a promising expedition into the treatment of ACC, investigates the potential of trabectedin, a marine-derived antitumoral agent, in inhibiting ACC cell invasiveness and metastasis. The researchers conducted preclinical studies using cell lines and zebrafish models to assess the effects of trabectedin on ACC cell behavior. Their findings suggest that trabectedin may offer a new weapon in the fight against ACC, potentially slowing the progression of the disease and improving patient outcomes.

Trabectedin: A New Hope for Adrenocortical Carcinoma Patients

The researchers' findings, like a beacon of light in the desert of ACC, suggest that trabectedin may offer a new hope for patients battling this aggressive form of cancer. The drug's ability to inhibit ACC cell invasiveness and metastasis, like a skilled camel driver guiding a caravan through treacherous terrain, offers a potential avenue for slowing the progression of the disease and improving patient survival.

The Importance of Preclinical Research in Cancer

This research underscores the importance of preclinical studies in cancer research. Just as explorers navigate uncharted territories, researchers in cancer are constantly seeking new and better treatments for this devastating disease. Preclinical studies, like a detailed map of the desert, provide valuable insights into the potential efficacy and safety of new drugs, paving the way for clinical trials and ultimately, improved treatments for patients.

Dr.Camel's Conclusion

This preclinical research offers exciting new insights into the potential of trabectedin as a treatment for adrenocortical carcinoma. The findings suggest that trabectedin may offer a new hope for patients battling this aggressive form of cancer, potentially slowing the progression of the disease and improving patient outcomes. Further research is warranted to validate these findings and bring this promising treatment to patients.

Date :
  1. Date Completed 2022-12-23
  2. Date Revised 2023-11-03
Further Info :

Pubmed ID

36449565

DOI: Digital Object Identifier

e220273

Related Literature

SNS
PICO Info
in preparation
Languages

English

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