Pre-therapeutic evaluation and practical management of cardiovascular and renal toxicities in patients with metastatic radioiodine-refractory thyroid cancer treated with lenvatinib.

Author: BagnisCorinne Isnard, BuffetCamille, EderhyStéphane, LeenhardtLaurence, WassermannJohanna

Paper Details 
Original Abstract of the Article :
Multi-receptor tyrosine kinase inhibitors with anti-angiogenic activity, particularly lenvatinib, have become the standard treatment for radioiodine-refractory metastatic differentiated thyroid cancer but are associated with a high incidence of toxicity. Although patients treated with lenvatinib hav...See full text at original site
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引用元:
https://doi.org/10.1080/14740338.2022.2153115

データ提供:米国国立医学図書館(NLM)

Managing Cardiovascular and Renal Toxicities in Lenvatinib-Treated Thyroid Cancer Patients

Thyroid cancer, a challenging condition often requiring targeted therapies, is frequently treated with lenvatinib, a multi-receptor tyrosine kinase inhibitor with anti-angiogenic activity. This research focuses on the cardiovascular and renal toxicities associated with lenvatinib treatment. Despite lenvatinib's efficacy in improving progression-free survival, these toxicities can lead to dose reductions, interruptions, or even complete withdrawal of the drug, potentially compromising its anti-tumor efficacy. The study aims to provide a comprehensive understanding of these toxicities and guide practical management strategies to optimize lenvatinib treatment.

Navigating Lenvatinib Treatment: Balancing Efficacy and Toxicity

The study emphasizes the need for a careful balance between lenvatinib's efficacy and its potential toxicities. This balance is like navigating a desert with limited resources, carefully managing the use of water and food to ensure survival. By understanding the risk factors and recognizing early signs of toxicity, clinicians can implement timely interventions to mitigate these adverse effects and ensure optimal treatment outcomes.

Protecting Your Heart and Kidneys: Managing Lenvatinib-Associated Toxicities

This research highlights the importance of vigilant monitoring for cardiovascular and renal toxicities in patients treated with lenvatinib. By recognizing and addressing these potential side effects early, healthcare professionals can protect the heart and kidneys, ensuring that patients can benefit from lenvatinib's therapeutic effects without compromising their overall health. This meticulous approach is akin to a desert traveler carefully checking their supplies and adjusting their route to avoid any potential hazards along the way.

Dr. Camel's Conclusion

Lenvatinib offers hope for patients battling thyroid cancer, but its use requires careful consideration of potential cardiovascular and renal toxicities. This study provides valuable insights into managing these risks, emphasizing the importance of early detection and prompt intervention. By taking a proactive approach, we can ensure that patients can benefit from lenvatinib's therapeutic effects while safeguarding their cardiovascular and renal health. Remember, even in the most challenging landscapes, with careful navigation and attention to detail, we can achieve our goals and overcome obstacles.

Date :
  1. Date Completed 2022-12-19
  2. Date Revised 2022-12-21
Further Info :

Pubmed ID

36458701

DOI: Digital Object Identifier

10.1080/14740338.2022.2153115

Related Literature

SNS
PICO Info
in preparation
Languages

English

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