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Effect of naproxen on the model lipid membrane formed on the water-chitosan subphase.

Author: JurakMałgorzata, PrzykazaKacper, WiącekAgnieszka Ewa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study examined the interactions of naproxen with a model biological membrane with and without the presence of chitosan. Chitosan suppressed some changes induced by naproxen, suggesting that it could reduce the undesirable effects of the drug.
Paper Details　
Original Abstract of the Article :
Non steroidal anti-inflammatory drugs (NSAIDs) are those of the most common over the counter (OTC) medications widely used by millions of people every day. Unfortunately, despite their popularity those drugs can cause serious side effects in the digestive system (ulcers, bleeding, and pain). These i...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbamem.2022.184099

データ提供：米国国立医学図書館（NLM）

Naproxen and Chitosan: Exploring Interactions with Model Membranes

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to alleviate pain and inflammation. However, these drugs can also cause adverse effects in the digestive system. This study investigates the interactions of naproxen, a common NSAID, with model biological membranes, exploring the potential of chitosan, a biocompatible polysaccharide, to mitigate these adverse effects.

The Role of Chitosan in Mitigating Naproxen's Effects: A Promising Approach

The study reveals that naproxen alters the mechanical and electrical properties of model membranes, potentially contributing to its adverse effects. However, the addition of chitosan to the system significantly modifies these properties, reducing the compressibility, thickness, and morphology of the membrane. This suggests that chitosan could potentially reduce the adverse effects of naproxen on the digestive system.

Chitosan: A Potential Protector Against Digestive Damage

This research offers a promising avenue for exploring the use of chitosan as a protective agent against the adverse effects of NSAIDs on the digestive system. By understanding the interactions between naproxen and model membranes, this study paves the way for developing new strategies to mitigate the gastrointestinal side effects of NSAIDs. This research is like finding a hidden oasis in the vast desert of pharmaceutical development, offering a potential solution to a common problem.

Dr.Camel's Conclusion

This study is like a camel caravan venturing into the desert of drug development, exploring the potential of chitosan to mitigate the adverse effects of naproxen. By understanding the interactions between drugs and model membranes, we can pave the way for safer and more effective treatments, ensuring that the benefits of medications outweigh any potential risks. This research is a beacon of hope, guiding us towards a future where medications can be used safely and effectively to improve human health.

Date :
  1. Date Completed 2023-02-06
  2. Date Revised 2023-02-21
Further Info :

Pubmed ID

36493856

DOI: Digital Object Identifier

10.1016/j.bbamem.2022.184099

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in preparation
Languages

English

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