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Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice.

Author: ChungEun Ji, HallowsKenneth R, HuangPolly, LiHui, MancinoValeria, Pastor-SolerNúria M, PhamJessica, PinkoskyStephen L, SaittaBiagio, SepehrSaman, WangJonathan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the potential of bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor, as a novel therapy for autosomal dominant polycystic kidney disease (ADPKD). In vitro and in vivo studies suggest that BA inhibits cyst growth and proliferation, improves mitochondrial function, and reduces ADPKD severity. Moreover, combining BA with tolvaptan, a current ADPKD treatment, leads to further improvements in ADPKD parameters. These findings suggest that repurposing BA might be a promising new therapy for ADPKD.
Paper Details　
Original Abstract of the Article :
ADPKD has few therapeutic options. Tolvaptan slows disease but has side effects limiting its tolerability. Bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor FDA-approved for hypercholesterolemia, catalyzes a key step in fatty acid/sterol synthesis important for cell proliferation. BA is act...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730828/

データ提供：米国国立医学図書館（NLM）

Bempedoic Acid: A Promising Oasis in the Desert of Polycystic Kidney Disease

Venturing into the world of nephrology, we find a study exploring the potential of bempedoic acid (BA), a drug used for hypercholesterolemia, as a novel treatment for polycystic kidney disease (ADPKD). The researchers investigated the effects of BA on cyst growth, proliferation, injury, and metabolic dysregulation in ADPKD cells and mice.

BA: A Potential New Weapon Against ADPKD

The study revealed that BA effectively inhibited cyst growth both in vitro and in vivo. This suggests that BA may be a promising new treatment option for ADPKD, potentially offering a more tolerable alternative to existing therapies.

Hope for a Healthy Desert: Managing ADPKD

This research provides a beacon of hope for individuals with ADPKD, highlighting the potential of repurposing existing medications for this challenging condition. It underscores the importance of ongoing research to find new and effective treatments for ADPKD.

Dr.Camel's Conclusion

This research is a breath of fresh air in the hot desert of ADPKD treatment. Bempedoic acid, a drug originally used for hypercholesterolemia, shows promise as a novel treatment for ADPKD. This research offers hope for a healthier future for individuals with this complex condition.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-20
Further Info :

Pubmed ID

36504724

DOI: Digital Object Identifier

PMC9730828

Related Literature

Article Analysis
・Side Effects of tolvaptan (kidney disease)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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