Primaquine-induced Severe Hemolysis in the Absence of Concomitant Malaria: Effects on G6PD Activity and Renal Function.

Author: AnsteyNicholas M, DouglasNicholas M, LeyBenedikt, PieraKim A, PriceRic N, RumasebAngela

Paper Details 
Original Abstract of the Article :
Primaquine prevents relapses of Plasmodium vivax malaria but can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The clinical and laboratory features of this outcome are usually confounded by the clinical and hemolytic effects of concomitant malaria. We d...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833077/

データ提供:米国国立医学図書館(NLM)

Primaquine: A Powerful Tool with Potential Pitfalls

Imagine a camel caravan traversing a vast desert, seeking refuge from the malaria parasite. Primaquine, a medication known for its effectiveness in preventing malaria relapse, is a valuable weapon in the fight against this disease. However, like a double-edged sword, primaquine can cause severe side effects, including hemolysis, in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

This case report describes a young man with G6PD deficiency who experienced severe hemolysis after taking primaquine. The patient's case highlights the potential dangers of primaquine in individuals with G6PD deficiency. This study underscores the importance of careful monitoring and prompt treatment in such cases.

Primaquine: A Double-Edged Sword in Malaria Treatment

This case report, like a cautionary tale from a seasoned traveler, serves as a reminder of the potential risks associated with primaquine. The findings highlight the importance of genetic testing and personalized care to ensure safe and effective use of this medication. Further research is needed to develop strategies for mitigating the risks of primaquine-induced hemolysis.

Navigating the Desert of Malaria Treatment with Caution

This case report encourages us to approach malaria treatment with a balance of caution and confidence. Primaquine, like a powerful yet delicate tool, requires careful handling and close monitoring to ensure patient safety. This study, a testament to the complexity of medical care, inspires us to continue seeking solutions that improve patient outcomes and minimize risks.

Dr. Camel's Conclusion

The findings of this case report, like a desert oasis offering both respite and caution, highlight the importance of understanding the nuances of medication use. Primaquine, a valuable tool in the fight against malaria, requires careful consideration and individualized care to ensure patient safety. This research, a reminder of the delicate balance between risk and benefit, inspires us to continue seeking solutions that improve patient outcomes and minimize risks.

Date :
  1. Date Completed 2023-01-13
  2. Date Revised 2023-01-27
Further Info :

Pubmed ID

36509054

DOI: Digital Object Identifier

PMC9833077

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Languages

English

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