Regorafenib and trifluridine/tipiracil in real clinical practice.

Author: García-BelosoNerea, Gayoso-ReyMónica, López-LópezAida, Piñeiro-CorralesGuadalupe, Robles-TorresDavid, Romero-VentosaElena Yaiza, de CastroNoemí Martínez-López

Paper Details 
Original Abstract of the Article :
BACKGROUND: Colorectal cancer is the ninth leading cause of death in Spain. The latest therapeutic developments in the advanced stages of this disease are the oral drugs trifluridine/tipiracil and regorafenib. OBJECTIVE: Results of clinical trials (CTs) are not in real conditions and therefore, we ...See full text at original site
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引用元:
https://doi.org/10.4103/jcrt.JCRT_1316_20

データ提供:米国国立医学図書館(NLM)

Regorafenib and Trifluridine/Tipiracil: Evaluating Real-World Effectiveness in Colorectal Cancer

The study delves into the real-world application of two oral drugs, regorafenib and trifluridine/tipiracil, used in treating advanced colorectal cancer. This study is like an expedition venturing into a vast desert, where the real-world challenges of treating this disease are laid bare. The researchers compared clinical trial findings with real-world outcomes, providing valuable insights into the effectiveness and safety profile of these drugs in actual clinical practice.

Unveiling the Realities of Colorectal Cancer Treatment

This study sheds light on the crucial difference between clinical trial data and real-world outcomes. It highlights the challenges of translating promising research findings into effective treatments for patients. The researchers found that the effectiveness of both drugs was lower in real-world practice compared to clinical trial results, demonstrating the need for further research to bridge the gap between clinical trials and real-world patient care.

Navigating the Desert of Colorectal Cancer

This study serves as a reminder that navigating the desert of colorectal cancer treatment requires a nuanced understanding of the disease and its complexities. It emphasizes the importance of real-world data in evaluating the effectiveness of treatments and developing more personalized approaches to patient care. As researchers continue to explore the landscape of colorectal cancer, we can expect to see even more innovative treatments emerge, ultimately leading to better outcomes for patients.

Dr.Camel's Conclusion

This study is like a journey through the vast desert of colorectal cancer treatment, revealing the true realities of managing this complex disease. The researchers are uncovering hidden truths and shedding light on the challenges of translating research findings into effective real-world solutions. As we continue to explore this terrain, we can expect to find new oases of hope for patients facing this difficult diagnosis.

Date :
  1. Date Completed 2022-12-14
  2. Date Revised 2022-12-22
Further Info :

Pubmed ID

36510990

DOI: Digital Object Identifier

10.4103/jcrt.JCRT_1316_20

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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