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Refractory fulminant colitis following ocrelizumab therapy requiring colectomy in a patient with multiple sclerosis.

Author: AnYoon-Kyo, BegunJakob, FernandesRichard, MalloyReuben

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a woman with relapsing-remitting multiple sclerosis treated with ocrelizumab who developed severe ocrelizumab-induced colitis. This highlights the potential for serious gastrointestinal complications associated with this treatment.
Paper Details　
Original Abstract of the Article :
A woman in her 40s was referred for acute and chronic postprandial abdominal cramps on a background of relapsing remitting multiple sclerosis on ocrelizumab therapy as well as coeliac disease on a gluten-free diet, with a family history of ulcerative colitis. Initial colonoscopy demonstrated mild pa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756195/

データ提供：米国国立医学図書館（NLM）

Navigating the Complexities of Ocrelizumab Therapy: A Case Study of Refractory Fulminant Colitis

Multiple sclerosis (MS) is a complex autoimmune disease that affects the central nervous system. This case study explores a rare but serious complication associated with ocrelizumab therapy, a treatment for MS. It's like navigating a complex desert landscape, where seemingly safe paths can lead to unexpected challenges.

Refractory Fulminant Colitis Following Ocrelizumab Therapy

This case study describes a patient with MS who developed refractory fulminant colitis following ocrelizumab therapy. Despite treatment with various medications, the patient's condition worsened, eventually requiring surgical intervention with a subtotal colectomy. This study highlights the importance of recognizing and managing potential adverse effects of medications, especially in patients with complex medical histories. This research is like discovering a hidden canyon in the desert, emphasizing the need for careful exploration and vigilance in managing unexpected challenges.

The Importance of Careful Monitoring and Management

This case study underscores the importance of careful monitoring and management of patients receiving ocrelizumab therapy, particularly for potential gastrointestinal complications. The findings highlight the need for prompt intervention and consideration of alternative treatment options when complications arise. It's like having a guide to navigate the desert: careful monitoring and proactive strategies can help avoid potential dangers.

Dr.Camel's Conclusion

This case study serves as a reminder that even with effective treatments, there can be unexpected complications. It emphasizes the importance of careful monitoring and prompt intervention to ensure patient safety. Like navigating a desert, managing complex medical conditions requires vigilance and a proactive approach to avoid potential pitfalls.

Date :
  1. Date Completed 2022-12-16
  2. Date Revised 2022-12-21
Further Info :

Pubmed ID

36517079

DOI: Digital Object Identifier

PMC9756195

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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