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The role of bDMARDs in idiopathic inflammatory myopathies: A systematic literature review.

Author: BargagliElena, CantariniLuca, ConticiniEdoardo, D'AlessandroMiriana, D'AlessandroRoberto, FalsettiPaolo, FredianiBruno, GrazziniSilvia, GugginoGiuliana, La BarberaLidia, RizzoChiara

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This systematic literature review examines the current evidence regarding the use of biologic disease modifying drugs (bDMARDs) in Idiopathic Inflammatory Myopathies (IIM), highlighting their effectiveness in treating refractory manifestations.
Paper Details　
Original Abstract of the Article :
Idiopathic inflammatory myopathies (IIM) are a group of different conditions typically affecting striate muscle, lung, joints, skin and gastrointestinal tract. Treatment typically relies on glucocorticoids and synthetic immunosuppressants, but the occurrence of refractory, difficult to treat, manife...See full text at original site
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引用元：
https://doi.org/10.1016/j.autrev.2022.103264

データ提供：米国国立医学図書館（NLM）

Treating Refractory Idiopathic Inflammatory Myopathies: The Rise of bDMARDs

Idiopathic inflammatory myopathies (IIM), a group of diseases affecting muscles, lungs, joints, skin, and the gastrointestinal tract, present a significant challenge for physicians. Traditional treatments, like glucocorticoids and immunosuppressants, often fall short in managing refractory cases. This systematic literature review examines the emerging role of biologic disease-modifying drugs (bDMARDs) in the treatment of IIM. The review assesses the available evidence on the use of bDMARDs in managing refractory IIM manifestations, focusing on the efficacy of different bDMARD agents for specific organ involvement.

The Promise of bDMARDs in Treating Refractory IIM

This literature review provides a comprehensive overview of the emerging evidence on the use of bDMARDs in the treatment of IIM. The review highlights the potential efficacy of TNF-α inhibitors, rituximab, tocilizumab, and abatacept in managing refractory IIM manifestations. The review also examines the use of anti-IL1 and anti-IL23 agents in treating specific IIM subsets. This information can guide clinicians in making informed decisions about the use of bDMARDs in managing refractory IIM.

A New Approach to Managing IIM

This research offers a glimmer of hope for patients battling refractory IIM. The increasing use of bDMARDs in managing this challenging disease holds the potential for improved treatment outcomes and a better quality of life for patients. This review highlights the importance of exploring new therapeutic options and the need for further research to refine the use of bDMARDs in treating IIM.

Dr.Camel's Conclusion

This systematic literature review provides valuable insights into the use of bDMARDs in treating refractory IIM. The review highlights the potential of these drugs in managing specific IIM manifestations and underscores the importance of personalized medicine in tailoring treatment to individual patient needs. This research emphasizes the need for continued investigation into the role of bDMARDs in treating IIM.
Date :
  1. Date Completed 2023-01-24
  2. Date Revised 2023-02-01
Further Info :

Pubmed ID

36549353

DOI: Digital Object Identifier

10.1016/j.autrev.2022.103264

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English

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