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High-Frequency Nanosecond Bleomycin Electrochemotherapy and its Effects on Changes in the Immune System and Survival.

Author: BalevičiūtėAustėja, GirkontaitėIrutė, KašėtaVytautas, Malyško-PtašinskėVeronika, NovickijJurij, NovickijVitalij, RadzevičiūtėEivina, ZinkevičienėAuksė, ŽelvysAugustinas

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

High-frequency nanosecond electrochemotherapy (nsECT) was shown to be effective in eliminating LLC1 tumors in C57BL/6J mice, leading to prolonged survival. nsECT induced significant changes in the immune system, including increased percentages of CD4<sup>+</sup> T, splenic memory B, and tumor-associated dendritic cell subsets, as well as increased levels of antitumor IgG antibodies. These findings suggest a promising alliance between nsECT and immunotherapy for cancer treatment.
Paper Details　
Original Abstract of the Article :
In this work, a time-dependent and time-independent study on bleomycin-based high-frequency nsECT (3.5 kV/cm &#215; 200 pulses) for the elimination of LLC1 tumours in C57BL/6J mice is performed. We show the efficiency of nsECT (200 ns and 700 ns delivered at 1 kHz and 1 MHz) for the elimination of t...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9776811/

データ提供：米国国立医学図書館（NLM）

Electrochemotherapy: A New Era in Cancer Treatment?

In the ongoing fight against cancer, researchers are constantly seeking innovative treatment strategies. This study delves into the potential of nanosecond electrochemotherapy (nsECT) combined with the drug bleomycin to eliminate tumors. Using a carefully designed experiment in mice, the researchers observed the effects of nsECT on tumor growth and the immune system. Their findings suggest that nsECT might not only be effective in shrinking tumors but also in stimulating an anti-tumor immune response.

A Powerful Combination for Cancer Treatment

The study found that nsECT significantly prolonged the survival of mice with tumors and induced notable changes in the immune system, including increased numbers of immune cells that attack tumors. These results highlight the potential of combining nsECT with immunotherapy to enhance the body's own fight against cancer.

Electrochemotherapy: A Potential Game Changer

This research opens up exciting possibilities for the future of cancer treatment. While further research is essential, this study suggests that nsECT might offer a promising avenue for fighting cancer. Remember, my dear friends, just like the desert wind shaping the dunes, we must constantly strive for innovation in our quest for effective cancer therapies.

Dr.Camel's Conclusion

This research explores the potential of nanosecond electrochemotherapy combined with bleomycin as a powerful cancer treatment. The findings suggest that this combination might offer a promising avenue for tumor elimination and even stimulate the immune system to fight cancer. While further research is needed, this study offers a glimpse into the future of cancer treatment.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-12-25
Further Info :

Pubmed ID

36551739

DOI: Digital Object Identifier

PMC9776811

Related Literature

Article Analysis
・Effects of bleomycin
SNS
PICO Info
in preparation
Languages

English

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