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Central Nervous System Toxicity of Voriconazole: Risk Factors and Threshold - A Retrospective Cohort Study.
Author: ChenJiaojiao, DongYalin, DuQian, LiSihan, QiuYulan, TengMengmeng, WangChuhui, WangQuanfang, WangTaotao, YangBo, YangLuting, ZhangYijing
Original Abstract of the Article :
Label="Purpose" NlmCategory="UNASSIGNED">Voriconazole (VRC) is an antifungal agent which is used for treatment and prophylaxis of invasive fungal infections. The common clinical adverse reactions mainly include central nervous system (CNS) toxicity and abnormal liver function. These adverse reaction...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766498/
データ提供:米国国立医学図書館(NLM)
Voriconazole: Unveiling the Risks and Thresholds of CNS Toxicity
Voriconazole, a powerful antifungal medication, is like a mighty camel traversing the vast desert of fungal infections. However, its use is not without potential risks. This study examines the intricate relationship between voriconazole and central nervous system (CNS) toxicity.
The authors conducted a retrospective cohort study to investigate the risk factors and thresholds for voriconazole-induced CNS toxicity. They analyzed data on patients receiving voriconazole treatment, aiming to identify factors that contribute to CNS toxicity and determine a safe threshold for plasma concentrations of the drug.
Their findings provide valuable insight into managing voriconazole therapy, helping to optimize treatment while minimizing the risk of CNS toxicity.
Balancing Benefits and Risks
This research highlights the importance of balancing the therapeutic benefits of voriconazole with the potential risks of CNS toxicity. By identifying risk factors and establishing a safe threshold for plasma concentrations, healthcare providers can make informed decisions about medication management.
Navigating the Desert of Antifungal Therapy
This study provides a valuable guide for navigating the intricate world of antifungal therapy, offering crucial insights into the safe and effective use of voriconazole. By understanding the potential risks and establishing safe thresholds, healthcare providers can optimize treatment outcomes for patients.
Dr.Camel's Conclusion
This study acts as a compass, guiding us through the potentially treacherous terrain of voriconazole therapy. By identifying risk factors and determining safe thresholds for plasma concentrations, we can ensure the safe and effective use of this important antifungal medication.
Date :
- Date Completed n.d.
- Date Revised 2022-12-24
Further Info :
Related Literature
English
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