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Apoptosis of Hematopoietic Stem Cells Contributes to Bone Marrow Suppression Following Chimeric Antigen Receptor T Cell Therapy.

Author: KingKatherine Y, MamonkinMaksim, MoFeiyan, ReadJay A, RouceRayne H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

CAR-T therapy can lead to cytokine release syndrome (CRS), which causes delayed bone marrow recovery. CRS increases levels of proinflammatory cytokines, leading to apoptosis and depletion of hematopoietic stem and progenitor cells (HSPCs).
Paper Details　
Original Abstract of the Article :
Chimeric antigen receptor (CAR) T cell (CAR-T) therapy represents a revolutionary treatment for patients with relapsed/refractory hematologic malignancies. However, its use can result in significant toxicities, including cytokine release syndrome (CRS), a potentially life-threatening clinical syndro...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36592718

データ提供：米国国立医学図書館（NLM）

CAR T Cell Therapy: Understanding the Bone Marrow Impact

Chimeric antigen receptor (CAR) T cell therapy is a revolutionary approach to treating hematologic malignancies. However, this therapy can also lead to significant side effects, including cytokine release syndrome (CRS) and prolonged bone marrow suppression. This research investigates the mechanism underlying this bone marrow suppression, exploring the potential role of proinflammatory cytokines in inducing apoptosis and depletion of hematopoietic stem and progenitor cells (HSPCs).

CRS and Bone Marrow Suppression: A Complex Interplay

The study’s findings provide compelling evidence that elevated levels of proinflammatory cytokines, particularly interferon-gamma (IFN-gamma), contribute to bone marrow suppression following CAR T cell therapy. This mechanism involves both increased apoptosis of HSPCs and enhanced proliferation of more committed progenitor cells, ultimately leading to cytopenias.

CAR T Cell Therapy: Navigating the Challenges

Understanding the complex interplay between CAR T cell therapy, CRS, and bone marrow suppression is crucial for optimizing treatment strategies and minimizing potential complications. Further research into mitigating these effects is essential for maximizing the benefits of this promising therapy.

Dr.Camel's Conclusion

CAR T cell therapy is a groundbreaking treatment for hematologic malignancies, but like a desert oasis that can be both a source of life and a hidden danger, it comes with potential side effects. This study provides valuable insights into the mechanisms behind bone marrow suppression, paving the way for improved strategies to manage this challenge and harness the full potential of CAR T cell therapy.

Date :
  1. Date Completed 2023-03-24
  2. Date Revised 2023-04-24
Further Info :

Pubmed ID

36592718

DOI: Digital Object Identifier

NIHMS1863185

Related Literature

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・Effective treatment of bone marrow diseases
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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