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Pathological Effects of Apalutamide in Lower-risk Prostate Cancer: Results From a Phase II Clinical Trial.

Author: DavicioniElai, EllisWilliam, GoyalSonia, GulatiRoman, HakanssonAlexander K, LinDaniel, LiuYang, MontgomeryBruce, NegaKatie, NelsonPeter S, PientaKenneth, SchadeGeorge, SchweizerMichael T, TrueLawrence, WrightJonathan, ZhaoYibai

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the potential of apalutamide to decrease active surveillance attrition rates for men with lower-risk prostate cancer. The hypothesis was that apalutamide could downstage tumors, potentially delaying the need for active treatment.
Paper Details　
Original Abstract of the Article :
Active surveillance is a safe and effective strategy for men with lower-risk prostate cancer who want to avoid local therapy; however, many patients on active surveillance progress to active treatment (eg, prostatectomy or radiation). We hypothesized that apalutamide would decrease active surveillan...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/36621991

データ提供：米国国立医学図書館（NLM）

Apalutamide: A Potential Game Changer for Lower-Risk Prostate Cancer

In the management of [lower-risk prostate cancer], we aim to find effective treatments that minimize the need for [local therapy], such as [prostatectomy or radiation]. This research explores the potential of [apalutamide] to achieve this goal.

This research investigates the hypothesis that apalutamide can [decrease active surveillance attrition rates] by [downstaging low-grade tumors]. It explores the potential of apalutamide to help patients with lower-risk prostate cancer avoid invasive treatments while achieving positive outcomes.

A Targeted Approach to Prostate Cancer

This research highlights a promising new approach to managing lower-risk prostate cancer, offering a potential alternative to invasive treatments.

Finding Less Invasive Solutions

This research offers hope for patients with lower-risk prostate cancer, seeking to find less invasive treatments that can effectively manage their condition. It's a reminder that, like a camel seeking the most efficient route through the desert, we must continually explore new and innovative approaches to medical treatment.

Dr. Camel's Conclusion

This study explores the potential of apalutamide as a promising new therapy for lower-risk prostate cancer, offering a potential alternative to invasive treatments and allowing patients to avoid unnecessary procedures while achieving favorable outcomes.

Date :
  1. Date Completed 2023-01-10
  2. Date Revised 2023-01-12
Further Info :

Pubmed ID

36621991

DOI: Digital Object Identifier

NIHMS1842500

Related Literature

Article Analysis
・Effects of apalutamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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