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Transdermal delivery of allopurinol to acute hyperuricemic mice <i>via</i> polymer microneedles for the regulation of serum uric acid levels.

Author: AharodnikauUladzislau E, JiangGuohua, LiuTianqi, NieLei, ShavandiAmin, SolomevichSergey O, SunYanfang, WangHan, WangRui, YunusovKhaydar E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated a new polymer microneedle (MN) system for transdermal delivery of allopurinol (AP) to treat acute hyperuricemia in mice. The MN system effectively reduced serum uric acid levels with fewer side effects compared to oral administration, promoting drug absorption and patient compliance.
Paper Details　
Original Abstract of the Article :
Allopurinol (AP) is widely used to treat hyperuricemia which may cause severe side effects upon oral administration. Alternative means for the treatment of hyperuricemia are demanded to simultaneously facilitate drug absorption, patient compliance, and fewer side effects. In this study, a new polyme...See full text at original site
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引用元：
https://doi.org/10.1039/d2bm01836e

データ提供：米国国立医学図書館（NLM）

Transdermal Delivery of Allopurinol for Acute Hyperuricemia: A New Path in the Desert of Treatment Options

[Hyperuricemia], a condition characterized by high levels of uric acid in the blood, can be a desert of discomfort. This study explores a new avenue for treating hyperuricemia, focusing on the transdermal delivery of [allopurinol] using [polymer microneedles]. The authors envision a future where medication can be delivered directly through the skin, avoiding the gastrointestinal complications often associated with oral administration.

Microneedles: Tiny Needles, Big Potential

This research showcases the potential of polymer microneedles as a novel delivery system for allopurinol. The study found that microneedles effectively reduced uric acid levels in mice while minimizing side effects compared to oral administration.

Navigating the Desert of Hyperuricemia: A More Comfortable Journey

This study opens a new door in the treatment of hyperuricemia, offering a promising alternative to oral medication. The potential for transdermal delivery of allopurinol holds the promise of increased patient compliance, reduced side effects, and a more comfortable journey for those navigating the desert of hyperuricemia.

Dr. Camel's Conclusion

The development of polymer microneedles for transdermal delivery of allopurinol represents a significant advancement in the treatment of hyperuricemia. This innovative approach offers a more convenient and less burdensome treatment option, potentially leading to better patient outcomes and improved quality of life.
Date :
  1. Date Completed 2023-03-01
  2. Date Revised 2023-03-01
Further Info :

Pubmed ID

36628631

DOI: Digital Object Identifier

10.1039/d2bm01836e

Related Literature

Article Analysis
・Side Effects of allopurinol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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